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Clinical Trials Week

Susan Hasty, Publisher

Table of Contents . . . April 5th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Trials Week | Other Publications

HIV/AIDS Therapy - Routine resistance testing can improve ART outcome in experienced patients

Transplant Medicine - Effect of CyA on big ET-1 levels 1 year after OHTx characterized

Breast Cancer - Oncologist calls for new guidelines on early reporting from clinical trials

Breast Cancer - Study demonstrates clear survival benefit of treatment in clinical trials

Cancer Therapy - Renal cancer human trial of phenoxodiol in combination therapy begins

Acute Coronary Syndrome - New study demonstrates the benefits of intensive statin therapy

Anthrax - ABthrax found to be safe and well tolerated

Benign Prostatic Hyperplasia - Milestone payments received, first patients treated with Prolieve

Brain Cancer - Hudson licenses radiosensitizer IPdR

Breast Cancer - Breast cancer patients switched to Aromasin more likely to remain cancer free

Breast Cancer - Caelyx demonstrates efficacy, reduced cardiac toxicity

Breast Cancer - Epirubicin, vinorelbine, and cisplatin are effective in advanced breast cancer

Breast Cancer - First large-scale trial of genetically personalized treatment to start soon

Breast Cancer - NDA filed with FDA for nanoparticle-based Abraxane

Breast Cancer - Preoperative treatment with anastrozole reduces need for extensive surgery

Breast Cancer - Results of comparison study favor exemestane for advanced disease

Breast Cancer - Study: Patients switched to AROMASIN more likely to remain cancer-free

Business & Finance - ESTRASORB maker announces revenue increase for quarter, decrease for 2003

Business & Finance - FluMist maker announces plan to achieve $2 billion in revenues by 2009

Cancer Therapy - Genetronics engages CRO for U.S. and European clinical trials

Cardiovascular Disease - Cardiac MRI a better predictor of heart attack, death for women

Cardiovascular Disease Therapy - Beta-blocker treatment feasible for many asthma, COPD patients

Cardiovascular Disease Therapy - Cardiac resynchronization reduces all-cause mortality risk

Chemotherapy-Induced Nausea - Aloxi injection incorporated into NCCN antiemetic guidelines

Chronic Hepatitis C - The ribavirin prodrug viramidine has proven safe in healthy volunteers

Chronic Obstructive Pulmonary Disease - COPD outcomes study completes patient recruitment

Chronic Pain Management - Company launches phase I clinical trials for chronic pain drug

Colon Cancer - Phase II colorectal vaccine trial results updated

Coronary Artery Blockage - Data supports performance of CYPHER Sirolimus-eluting Coronary Stent

Diagnostics - Positive PYY obesity and apomorphine sexual dysfunction trial data reported

Diarrhea - Trial results advance development of vaccine for travelers' diarrhea

Ear Infections - FDA approves once-daily Floxin Otic (ofloxacin otic solution)

Finance - Autoimmune disease drug maker completes raises $57 million

Finance - Trial-monitoring company announces final closing of private financing

Finance - Vaccine development helps drive company's 25% revenue increase in 2003

Finance - Women's health pharmaceutical firm reports loss of $0.20 per share

Glaucoma - Clinical data on Travatan/Timolol Fixed Combination reported at glaucoma meeting

Heart Failure - Implantable defibrillators reduce death by 23% in trial

Heart Failure - Study raises questions about chronic diuretics and renal insufficiency

Herpesvirus - Common virus may contribute to uncommon bone disease in children

Hypertension Therapy - Bosentan represents improved approach for pulmonary arterial hypertension treatment

Immunology - Data presented on molecular mechanism of action for HE2000

Immunology - Positive results reported from Xibrom U.S. phase III trials

Informed Consent - Medical privacy law makes health research harder, more expensive

Insomnia - Company sees positive results for indiplon in adults with transient insomnia

Licensing Agreement - Geron Corp. inks agreement for therapeutic cancer-vaccine technology

Liver Cancer - First patient accepted in phase III liver cancer study

Melanoma - Board recommends continuations of Canvaxin phase III trial

Myocardial Infarction - Pexelizumab mortality benefit reported from multiple trials

Myocardial Infarction - Study demonstrates efficacy of automated external defibrillator

Overactive Bladder - Phase I trial for Oxybutynin gel completed

Pain Therapy - First patients dosed in phase II AeroLEF trial for post-surgical pain

Solid Tumors - 2-Deoxy-D-Glucose phase I trial initiated for solid tumor treatment

Squamous Cell Carcinoma - Docetaxel, cisplatin and 5-FU are effective in squamous cell carcinoma

Staph Infections - Company initiates enrollment in phase II trial for Aurexis

Stroke - Stent trials demonstrate positive outcomes in high-risk patients

Systemic Lupus Erythematosus - LymphoStat-B selected for FDA's Pilot 2 Program

Tumor Suppression - ARRY-142886 cleared to advance into human clinical trials

Vaccine Efficacy - Vaccination for neurotropic disease recommended in children with brain tumors

Wound Care - Study demonstrates HealthRenu effectiveness in infection prevention

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