Cardiopulmonary Bypass

Postoperative fibrinolysis in pericardial cavity characterized

Published in Clinical Trials Week, December 6th, 2004

Fibrinolytic activity in the pericardial cavity after cardiopulmonary bypass surgery has been characterized.

"Aprotinin is frequently administered systemically in patients undergoing cardiopulmonary bypass to preserve platelet function and ameliorate excessive activation of fibrinolysis," scientists in Germany explained. "More recently, aprotinin topically applied in the pericardial cavity was also found to improve postoperative blood loss."

"However, platelet activation was not reduced locally during surgery," noted P.N. Khalil and colleagues at the University of Hamburg. "Hence, we investigated in the present prospective, in a randomized...

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Source: Clinical Trials Week (2004-12-06)

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