Anemia Therapy

Third course of anti-thymocyte globulin in aplastic anemia studied

Published in Clinical Trials Week, June 6th, 2005

A third course of anti-thymocyte globulin in aplastic anemia is only beneficial in previous responders.

According to a study from England, "This retrospective study evaluated the outcome of 18 patients with aplastic anemia treated with a third course of anti-thymocyte globulin (ATG)-containing immunosuppressive therapy (IST). Of the 18 patients, seven had responded to one of the previous courses of ATG and 11 were refractory to both the previous courses."

"Self-limiting grade {{>=}} 3 liver toxicity was observed in three patients. Two patients had to discontinue ATG because of severe systemic side effects. The incidence and manifestations of serum...

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Source: Clinical Trials Week (2005-06-06)

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