Clinical Trials Week

Gastroesophageal Reflux Disease - Nizatidine for the treatment of pediatric GERD is safe and effective

Gene Transfer - Company licenses gene delivery technology for cardiovascular efforts to AnGes MG

Geriatric Depression - Sleep deprivation lowers paroxetine efficacy

Geriatrics - Acute phase mediators analyzed in hospitalized geriatric patients

Glioma - Clinical data: Cotara holds promise for treating brain cancer

Glioma - Trial results of monoclonal antibody in malignant glioma tumors reported

Graft-Versus-Host Disease - High doses of transplanted CD34+ cells linked to lower risk of graft rejection

Growth Hormone Insensitivity Syndrome - Insmed reports results from clinical trial of SomatoKine replacement therapy

HIV Vaccine - Sexual risk behavior is high among vaccine efficacy trial subjects

HIV/AIDS Prevention - New findings in the area of HIV/AIDS prevention described

HIV/AIDS Therapy - Biopharmaceutical company announces trial of therapy for drug-naive HIV patients

HIV/AIDS Therapy - Preclinical data presented for two protease inhibitor drug candidates

Hepatic Resection - Pathologic predictors of survival after resection of liver cancer appraised

Hepatitis B - Good 2-yr data for Telbivudine for treatment of chronic hepatitis B presented

Hepatitis B Virus - Dermatological disorders associated to hepatitis B virus infection in Turkey

Hepatitis C - Hyperhomocysteinemia and MTHFR C677T polymorphism promoted steatosis

Hepatitis C - Pharmaceutical company receives IND clearance for antiviral clinical trial

Hepatitis C - Results of phase IIb trial of the hepatitis C therapeutic E1 vaccine reported

Hepatitis C Treatment - Pharmaceutical group completes enrollment of valopicitabine Phase IIb Trial

Hepatitis C Virus - Compartmentalization of HCV genotypes between plasma and PBMC observed

Hepatitis C Virus - Human serum facilitated hepatitis C virus infection

Hepatitis C Virus - Mitogen upregulated hepatitis C virus expression in human lymphoid cells

Hepatocellular Cancer - Clinicopathological importance of EZH2 mRNA expression in liver cancer analyzed

Hepatocellular Cancer - Iodine concentration improved diagnostic efficacy of biphasic spiral CT

Hodgkin Lymphoma - Interleukin-4 cytotoxin may be a unique agent against Hodgkin lymphoma

Hypertension - Company initiates phase II trial for Ventavis in expanded indication

Hypertension - Researchers' findings advance hypertension research

Inflammatory Disease Therapy - BIRB796 inhibits all p38 MAPK isoforms

Information Technology - USC-CHLA pediatric clinical research selects clinical data management system

Ingrown Toenail - Chemical ablation superior to Zadik procedure

Leukemia - Activation of the RAS pathway predicted chemosensitive phenotype of AML blasts

Leukemia - Early versus late insertion times of central venous lines compared

Leukemia - Genetic classification of adult acute lymphoblastic leukemia performed

Leukemia - Role of transplantation for infants with acute lymphoblastic leukemia defined

Lichen Planus - Outcome and clinical features of mucosal vulval lichen planus discussed

Liver Cancer - Alpha enolase overexpressed in hepatitis C virus-related liver cancer

Liver Cancer - Cigarette smoking associated with hepatocellular carcinoma

Liver Cancer - Fatigue patterns of male liver cancer patients examined

Liver Cancer - Serum human telomerase reverse transcriptase messenger RNA used as tumor marker

Liver Cancer - Studies advance knowledge in liver cancer research

Liver Failure - Etiology and prognosticators of pediatric fulminant hepatic failure profiled

Liver Function - Phosphorus-31 MR spectroscopy assessed pediatric liver transplant recipients

Liver Injury - Incidence of drug-induced liver injury in medical inpatients reviewed

Liver Transplant - Hepatitis C infection increased risk of new-onset diabetes after transplantation

Lung Cancer - Ethnic disparities in treatment of stage I non-small cell lung cancer examined

Lung Cancer - Gefitinib treatment improved symptoms and quality of life in NSCLC patients

Lung Cancer - Xcytrin Injection lung cancer with brain metastases trial data reported

Lupus Erythematosus - Immunomedics initiates two pivotal phase III trials in lupus

Lupus Erythematosus - Pharmaceutical company provides update finances, trials on lupus renal drug

Lymph Edema - "White bowel" designated a sonographic sign of intestinal lymph edema

MALT Lymphoma - High relapse rate in patients with MALT lymphoma warranted lifelong follow-up

Macular Degeneration - Macugen approved in Brazil for the treatment of neovascular AMD

Malaria Therapy - Artesunate-clindamycin regimen with short half-life effective

Melanoma - Case-control study identified melanoma risk factors in Belgian population

Metastatic Melanoma - Biopharma company reports phase 2 results in tablostat melanoma trial

Multiple Myeloma - Phase I clinical trial for CHIR-258 begins

Myelodysplastic Syndrome - Clinical features of Chinese patients with MDS compared with Western patients

Myelodysplastic Syndrome - Single-nucleotide polymorphism of G-CSF receptor gene heightened risk for MDS

Myeloid Dysplasia - Flow cytometry diagnosed erythroid and myeloid dysplasia

Myeloma - MRI findings correlated with histological results in multiple myelomas

Neovascularization - Retinal vasculature and retinopathy studied, effect of bicarbonate revealed

Non-Hodgkin Lymphoma - Patients being enrolled in Rituxan trial for follicular NHL

Oral Mucositis - Single-dose phase I data on velafermin (CG53135) announced

Osteoarthritis - Barriers to clinical trial enrollment identified

Osteomyelitis - Efficacy of antibiotic treatment evaluated

Pain Management - Pharmaceutical company provides preclinical test results on pain treatment

Pain Medicines - Pain from urethrocystoscopy evaluated in patients with bladder cancer

Pancreatitis - Gallstone pancreatitis correlated to passed stone

Patents - Danish oncology company receives broad U.S., E.U. patents for HDAC inhibitors

Patents - Patent issued for mutated interleukin 13 technology to treat malignant glioma

Patents - Transdermal-DNA developer files provisional U.S. patent for Down syndrome test

Patents - U.S. patent granted for modified pectin drugs to treat angiogenesis diseases

Patient Costs - Effect of clinical characteristics on patient costs examined

Percutaneous Coronary Intervention - Patients with prior PCI have a lower mortality rate than those without prior PCI

Personnel - Lead investigator named for multiple sclerosis drug trial

Personnel - Pharmaceutical company strengthens development team

Personnel - Thomas R. Beck, MD, named VP business and product development

Pharmaceutical Research - Study focuses on pharma product commercialization

Pharmaceuticals - Gastrointestinal-focused pharmaceutical company submits NDA proton inhibitor

Population Studies - Cancer survival examined in Kampala, Uganda

Prostate Cancer - Anti-cancer vaccine proof of concept study in men with HDPC completed

Prostate Cancer - Feasibility of 3D proton MR spectroscopic imaging of prostate cancer studied

Prostate Cancer - U.S. FDA authorizes clinical trial in drug for hormone dependent prostate cancer

Proteasome Inhibitors - Bortezomib efficacy assessed in patients with advanced cancer

Psoriasis - Company reports successful efficacy trial for topical treatment of psoriasis

Pulmonary Arterial Hypertension - New STRIDE-2 data presented at American Thoracic Society meeting

Rectal Cancer - Factors influencing sexual function in patients with rectal cancer characterized

Respiratory Medicine - Hybridon announces collaboration to develop immune modulatory (IMO) compounds

Rheumatoid Arthritis - Intramuscular gold augments weak response to methotrexate

Schizophrenia - Seroquel and risperidone improve cognitive function

Schizophrenia - Sustained-release bupropion can aid smoking cessation

Sexual & Reproductive Health - Data: Cialis improves erectile function in ED patients with comorbid conditions

Short Stature - New method of growth hormone dosing improves height

Sinus Node Dysfunction - Prolonged QRS duration linked to mortality risk during pacemaker therapy

Squamous Cancer - MMP-2 and MMP-9 activated in patients with oral squamous cell carcinoma

Steatohepatitis - Pediatric patients affected by nonalcoholic steatohepatitis

Stroke - Biotechnology co. chooses corporation to manage ischemic stroke treatment trials

Surgical Technology - Autologous thrombin processing device receives CE Mark to allow sales in Europe

T-Cell Lymphoma - Encouraging results seen in phase II trial for peripheral T-cell lymphoma

Thrombosis - Complications arose from subcutaneous infusion ports

Transplant Medicine - Non-steroid therapy after liver transplant comparable to steroids, study shows

Travelers' Diarrhea - Rifaximin shows promise for prevention

Ulcerative Colitis - REMICADE supplemental biologics license application up for review

Urology - Positive data reported in a phase II study of benign prostatic hyperplasia drug

Vaccine Development - Biopharma company initiates S. Epidermidis vaccine phase I study