Myelodysplastic Syndrome
Single-nucleotide polymorphism of G-CSF receptor gene heightened risk for MDS
Published in Clinical Trials Week, June 27th, 2005
"The G-CSF-R transmits signals for proliferation and differentiation of myeloid progenitor cells. Here we report on the identification of a rare single nucleotide polymorphism within its intracellular domain (G-CSF-R_Glu-785-Lys)," scientists writing in the journal Blood reported.
"Screening a cohort of 116 patients with primary myelodysplastic syndromes (MDS), de novo acute myeloid leukemia (AML) (84 patients), as well as 232 age-and sex-matched controls revealed a highly significant association...
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Source: Clinical Trials Week (2005-06-27)
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