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Anti-Inflammatory Mediators

Cerebrospinal fluid concentrations of anti-inflammatory mediators measured

Published in Clinical Trials Week, June 27th, 2005

The cerebrospinal fluid concentrations of anti-inflammatory mediators in early-phase severe traumatic brain injury (TBI) were measured.

According to recent research from Japan, "In our previous study of patients with early-phase severe TBI, the anti-inflammatory interleukin (IL)-10 concentration was lower in cerebrospinal fluid (CSF) than in serum, whereas proinflammatory IL-1beta and tumor necrosis factor (TNF)-alpha concentrations were higher in CSF than in serum."

"To clarify the influence of additional injury on this disproportion between proinflammatory and anti-inflammatory mediators, we compared their CSF and serum concentrations in patients...

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