Published in Clinical Trials Week, September 5th, 2005
"Intragastric acid suppression is the most direct measure of the pharmacodynamic efficacy of proton pump inhibitors, which are the most effective drugs for acid-related diseases," according to gastroenterologists in the United States, who compared "the effectiveness of once and twice daily dosing of lansoprazole and esomeprazole in controlling intragastric acidity (target gastric pH >4.0) over a 24-hour period."
"In an open-label, two-way crossover study, 45 Helicobacter pylori-negative patients with gastro-esophageal reflux...
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