Clinical Trials Week

Chronic Daily Headache - High-dose Botox shows promise as prophylactic treatment

Clinical Trials - Study shows interferon treatment delays MS onset in patients showing clinical signs

Crohn Disease - Phase II Trial results for treatment of Crohn Disease with Cimzia are positive

Drug Development - Data being analyzed in phase II CoFactor trial in patients with metastatic colorectal cancer

Erectile Dysfunction - Tadalafil effective during thiazide diuretic hypertension therapy

Adverse Drug Reaction - Tysabri safety evaluation complete; no new confirmed cases of PML

Alcoholism Therapy - Increasing leptin levels precede relapse in detoxified alcoholics

Allergy & Immunology - Hepatitis C virus therapy alters the efforts of natural killer T cells

Angiology - C-reactive protein elevation correlates with accelerated atherogenesis in rheumatoid arthritis

Angiology - Computed tomography is of limited diagnostic value in evaluating CAD

Breast Cancer - Researchers report details of new studies and findings in the area of breast cancer

Angiology - Coronary artery stenoses detected using multi-detector computed tomography

Angiology - Flow cytometry of platelet-leukocyte aggregates may permit monitoring of platelet function

Angiology - Flow-mediated vasodilation predicts the presence and extent of coronary artery disease

Angiology - Phenylephrine increases blood flow in the radial artery used as a coronary bypass conduit

Asthma Therapy - Research add new data to asthma therapy body of knowledge

Bioterrorism - Positive data presented from preclinical and clinical studies with Neumune

Blood Clotting - Coagulation system is activated in Duchenne muscular dystrophy patients with cardiac dysfunction

Breast Cancer - Data shows Herceptin plus chemotherapy reduces risk of breast cancer recurrence

Breast Cancer - Reports add new data to breast cancer research

Breast Cancer Risk Factors - Mammographic density indicated as marker of breast cancer risk

Business & Finance - Avid Bioservices to provide development services for monoclonal antibody

Business & Finance - Cancer-focused biopharmaceutical company raises $11.6 million in private funding

Business & Finance - Defibrotid maker completes $10.9 million private placement

Business & Finance - Drug-delivery company returns to profitability in the third quarter

Business & Finance - Pharmaceutical company updates program for lupus renal disease drug candidate

Cancer Research - National council research assistance program gets support from national program

Cancer Therapy - New trial to investigate combination of HYB2055 with chemotherapy

Cancer Therapy - Preliminary results reported from randomized phase II trial of Avastin and Tarceva in kidney cancer

Cardiology - Basis of paroxysmal atrial fibrillation can be predicted by gender and left atrial enlargement

Cardiology - Catheter ablation sites identified in patients with ventricutar tachycardia

Cardiovascular Disease - Analysis suggests Cypher Stent more cost effective than bypass surgery

Cardiovascular Disease - Phase 1 study underway of rFXIII for patients undergoing cardiac surgery

Caregiving - Patient/caregiver symptom control intervention evaluated

Chemotherapy - Irinotecan plus temozolomide was well tolerated in malignant glioma patients

Chemotherapy - Temsirolimus used to treat relapsed mantle cell lymphoma

Clinical Trials - Clevidipine phase 3 program resumes, phase 3 interim data affirms safety profile

Clinical Trials - Clinical trials data show excellent long-term safety, efficacy of stent system

Clinical Trials - Clinical trials should adopt routine genetic testing and risk stratification

Clinical Trials - Complete clinical, angiographic data confirm patient safety of drug-eluting stent

Clinical Trials - DNA 'prime-boost' vaccine technology enters phase 2 clinical trial for HIV

Clinical Trials - Data from four studies finds multiple overlapping stents better for high-risk patients

Clinical Trials - Enrollment complete in phase 3 study of Evamist for treating menopausal symptoms

Clinical Trials - Health Canada grants clearance to initiate phase 2 cancer trial for Proxinium

Clinical Trials - Phase 2 clinical trial of drug candidate for allergic asthma patients initiated

Clinical Trials - Phase 2 testing of HIV vaccine developed with Vaccine Research Center initiated

Clinical Trials - Prostate cancer trial ended, metastatic breast cancer trial continues, company reports

Clinical Trials - Recruitment strategies for Osteoporotic Fractures in Men Study discussed

Clinical Trials - Results of phase 3 trial on immunotherapy Virulizin for pancreatic cancer reported

Clinical Trials - Stent system clinical trial shows reduction of restenosis in diabetic patients

Clinical Trials - Value of websites on cancer clinical trials need further study

Collaborations - ABC(2) and collaborator announce second brain cancer collaboration

Collaborations - Electronic data management partnership signed for managing clinical trial data

Colon Cancer - Genasense Injection increases anticancer activity of radiation

Colorectal Cancer - Carbohydrate compound company begins phase II trail of Davanat /5-FU

Colorectal Cancer - TroVax trial achieves primary endpoints for cancer immunotherapy treatment

Contraception - First scientific data for Lybrel presented at ASRM meeting

Dermatology - Data: Remicade can quickly and significantly improve psoriasis symptoms

Dermatology - Few patients with lichen planus in Iran have underlying hepatitis C infections

Diabetes Therapy - Tesaglitazar improves metabolic abnormalities linked to insulin resistance

Diabetic Neuropathy - Studies show QR-333 safe for topical use

Diagnostics - Endometrial cytology diagnosed endometrial cancer with normal curettage findings

Diagnostics - Myocardial perfusion imaging is imperfect in the absence of post-test referral bias

Diagnostics - Noninvasive scintigraphy is useful in the etiologic diagnosis of cardiac amyloidosis

Diagnostics - PET/CT with intravenous contrast used for PET attenuation correction

Disease Associations - Cardiac troponin I predicts adverse events in stable coronary disease

Disease Associations - Coronary microembolization ultrasonically detected during percutaneous coronary interventions

Disease Associations - Elevated brain natriuretic peptide is diagnostic of chronic obstructive pulmonary disease

Disease Associations - Epithelioid hemangioendothelioma of the mitral valve may be diagnostic of valve tumors

Disease Associations - Intima-media thickness score from carotid and femoral arteries predicts extent of CAD

Disease Associations - Palmoplantar keratoderma associated with esophagus squamous cell cancer

Disease Associations - Prior aspirin use is not a marker of increased mortality in elderly patients with acute MI

Dosimetry - Amifostine allows additional delivery of paclitaxel in patients undergoing radiotherapy

Drug Development - ACT 4 study initiated in acute treatment of atrial fibrillation

Drug Development - Enrollment strong in Phase III trials of treatment for pulmonary fibrosis

Drug Development - First patients enrolled, treated in IRX-2 phase II head and neck cancer study

Drug Development - Malaria drug positioned for treatment in pregnant, lactating women

Drug Development - Phase I trial for CHIR-12.12 initiated in multiple myeloma

Drug Development - Phase I trial of AG-707 therapeutic vaccine for genital herpes initiated

Drug Development - Phase II trial of PPI-0903 initiated in patients with bacterial infections

Drug Development - U.S. FDA maintains clinical hold on IND application for RESUS phase II/III trial of Hemopure

Duchenne Muscular Dystrophy - Development-stage biopharma targets January 2006 to submit IND application for Myodur In DMD

Eczema - Research shows benefits of Elidel in eczema patients as alternative to steroids for eczema patients