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Diabetes Therapy

Rosiglitazone eased postprandial neutrophils and proinflammatory cytokines rises in diabetes

Published in Clinical Trials Week, June 22nd, 2006

Rosiglitazone eased the postprandial increases of neutrophils and proinflammatory cytokines in patients with type 2 diabetes.

"We postulated that in type 2 diabetes, the postprandial phase is a proinflammatory state that can be modulated by PPAR-gamma agonists. For this purpose, we determined the effects of rosiglitazone (8 mg/d) on postprandial leukocyte counts and proinflammatory cytokines (IL-6 and IL-8) in patients with type 2 diabetes," scientists in Netherlands report.

J.P.H. van Wijk and colleagues working with the University of Utrecht explained, "A randomized, 8-week, cross-over, placebo-controlled, double-blind clinical trial was performed...

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