Clinical Trials Week
Susan Hasty, Publisher
Table of Contents . . . July 17th, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Clinical Trials Week | Other Publications
Biliary Tract Cancer - Biliary tract cancer risk reduced by tea drinking
Cardiology - Myocardial infarct size is measurable with MRI using 0.1-0.2 mmol/kg contrast dose
Clinical Trials - Periodontal infections cause changes in traditional and novel cardiovascular risk factors
Coronary Artery Disease - Coronary artery disease risk may be reduced by LycoRed therapy
Hypertension - Rilmenidine improves glucose and lipid metabolism and endothelial function in hypertensive
Age-Related Macular Degeneration - Age-related macular degeneration is linked to retinal iron accumulation
Anesthesia - Doxapram shortens recovery following sevoflurane anesthesia
Angina - Ranexa reduces angina frequency and nitroglycerin consumption in trial
Assisted Reproduction - Metformin increases pregnancy rate in infertile women after laparoscopic ovarian drilling
Atherosclerosis - AstraZeneca Crestor combination trial reports largest LDL-C reduction in patients
Atopic Dermatitis - Anacor reports promising data on drug candidate for itchy, inflamed skin
Avian Influenza - Researchers begin trial to test the effectiveness of a new bird flu vaccine
Avian Influenza - Sinovac reports positive phase 1 preliminary trial results on bird flu vaccine
Breast Cancer - Breast cancer outcome after preoperative or postoperative docetaxel discussed
Breast Cancer - Breast cancer patients who elect for surgical treatment can be offered sentinel lymph node biopsy
Breast Cancer - Breast cancer survival improved by dose-dense sequential chemotherapy
Breast Cancer Vaccine - HER2/neu-derived peptide GP2 promising for use in breast cancer vaccine
Burn Care - Partial-thickness burn care with AQUACEL Ag is clinically and economically beneficial
Burn Care - Pediatric burn scar quality is improved by angiogenesis protein
Business Update - Compound Therapeutics becomes Adnexus Therapeutics
Business Update - Corgentech changes name to Anesiva to reflect focus on robust pipeline of pain therapeutics
Business Update - Cytokinetics announces extension of research collaboration with GlaxoSmithKline
Business Update - DataLabs announces launch of Site Manager 2.0, an advanced clinical trial management portal
Business Update - Debiopharm, Sigma-Tau sign license agreement for acute heart failure treatment istaroxime
Business Update - Invivodata completes strategic initiatives, expands patient outcomes reporting software
Business Update - Medidata Solutions, Cytel offer patient randomization option in EDC clinical trial software
Business Update - U.S. government to purchase Human Genome Sciences' ABthrax for Strategic National Stockpile
Cancer Therapy - Combination immunogene therapy explored for glioblastomas and melanomas
Cancer Therapy - Perifosine inhibits Akt and induces cytotoxicity in human multiple myeloma cells
Cancer Therapy - Scorpion venom offers promising experimental brain-cancer therapy
Cancer Therapy - Solid cancers and angiogenesis bow to drug regimens containing a mixture of low-dose drugs
Cardiac Medical Devices - St. Jude Medical announces QuickOpt optimization clinical trial results
Cardiac Medical Devices - SyntheMed reports positive results from European clinical study of REPEL-CV adhesion barrier
Cardiac Transplantation - Tacrolimus with mycophenolate mofetil advantageous in cardiac transplantation
Cardiology - Cardiopulmonary bypass patients cannot be monitored with continuous CO measurement
Cardiology - Synthetic Blood receives letter to initiate cardiopulmonary bypass surgery trial in Mexico
Cardiology - Systolic dysfunction and mild heart failure patients are treated with spironolactone
Cardiovascular Disease - Aortic stenosis progression is considered in review emphasizing emerging medical treatments
Cardiovascular Disease - In non-ST-elevation acute coronary syndrome, NT-proBNP predicts severity of coronary lesions
Chronic Kidney Disease - Advanced Magnetics reports panel identifies no safety issues for ferumoxytol phase III trial
Chronic Myeloid Leukemia - ChemGenex presents data on Ceflatonin for treating CML patients resistant to Gleevec
Clinical Trials - Biocompatibles International plc delivers clinical trials update
Clinical Trials - Devax initiates enrollment in clinical trial with Axxess Drug Eluting Stent System
Clinical Trials - Health Market Science announces release of national investigator recruitment database
Clinical Trials - NeurogesX completes enrollment in Phase 3 postherpetic neuralgia trial
Clinical Trials - New data on renin inhibitor SPP100 (Rasilez) demonstrates potential use in diabetic patients
Clinical Trials - Novacea announces preliminary results of Phase 1/2 clinical trial in non-small cell lung cancer
Clinical Trials - Nymox reports completion of NX-1207 dosing in multicenter BPH drug trial
Collaborations - IDDI, Cytel join to provide advanced randomization platform and services for trials
Collaborations - SR Pharma subsidiary Atugen collaborates to manufacture anticancer drug to GMP production
Colon Cancer - Colon and rectosigmoid cancer short-term outcome after laparoscopic resection assessed
Colorectal Cancer - Avastin approved in combination with chemotherapy for second-line metastatic colorectal cancer
Colorectal Cancer - Colorectal cancer treated by combined irinotecan and oxaliplatin given every 3 weeks
Complementary & Alternative Medicine - Chiropractic care reduced heart rate and pain in a multisite clinical study
Dental Research - Implant-retained mandibular overdentures require more treatment time and interventions
Dermatology - Skin benefits from Licochalcone A therapy when applied to sensitive or irritated skin
Diabetes Research - Diabetes prevention trial enrolls first patients, seeks additional volunteers in three states
Diabetes Therapy - Novartis unveils efficacy data for Galvus, an investigational oral diabetes compound
Diabetic Retinopathy - Macular profiles of diabetic retinopathy patients may predict response to therapy
Diet & Nutrition - Scientists have discovered what may be a successful non-dietary therapy for celiac sprue
Drug Development - Anti-cancer therapeutic from Adnexus to start clinical trials
Drug Development - Athenagen advances angiogenesis drug to clinical testing
Drug Development - Avigen initiates AV650 phase I study for neuromuscular spasticity
Drug Development - CuraGen initiates Phase I clinical trial with CR011-vcMMAE for metastatic melanoma
Drug Development - FermaVir announces new preclinical oral bioavailability data for FV-100 for shingles
Drug Development - Organon starts phase III development of combined oral contraceptive
Drug Development - Panacos announces Phase 2b clinical trial of HIV maturation inhibitor Bevirimat
Drug Development - Preclinical trials show small molecule arthritis drug not metabolized in liver
Dupuytren Disease - Auxilium announces results from study of AA4500 in Dupuytren disease
Epidemiology - Ala aminotransferase level predicts HCV-associated hepatocellular carcinoma
Finance - Epeius Biotechnologies awarded $400,000 grant by Lazarex Cancer Foundation for gene trials
Finance - Sangamo BioSciences announces common stock offering to raise net $20.15 million
Finance - XenoPort prices public offering of 4,500,000 shares of common stock at $17 per share
Gastric Cancer - New gastric carcinomas prevented by eradicating Helicobacter pylori after endoscopic resection
Gout Research - PEG-uricase trial results show anti-hyperuricemic effect in treatment-failure gout patients
HIV Vaccines - Bio-Bridge reports favorable safety, immunogenicity results from study of oral HIV vaccine
HIV/AIDS Therapy - Immune Response completes first enrollments, receives OK to expand phase 2 trial of HIV drug
HIV/AIDS Vaccine - Vectored vaccines expressing HIV-1 gag coupled to T cell epitopes induce HIV-specific T cells
Head & Neck Cancer - Head and neck cancer poor prognosis correlated with numerical aberrations of chromosomes X and 11
Head & Neck Cancer - Head and neck cancer-related tumor hypoxia detected by positron emission tomography
Heart Failure - Diastolic and systolic heart failure are the extreme phenotypes on a single-disease spectrum
Heart Failure - Study data suggest Aranesp (darbepoetin alfa) may decrease anemia risk related to heart failure
Hepatitis C Virus - Hepatitis C viral infection is associated with myocarditis and heart failure
Hypogonadism - Indevus completes enrollment in pharmacokinetic trial for Nebido
Influenza Vaccine - Stanford-Lucile Packard Children's Hospital seeks adult volunteers for influenza study
Influenza Vaccine - Trivalent inactivated influenza vaccine with biovector mucosal adjuvant shows promise
Insomnia - Arena Pharmaceuticals presents favorable results from phase I studies of insomnia compound
Ischemia - Acute MI patients undergoing PCI are likely to be treated with post- rather than pre-conditioning
Kawasaki Disease - Kawasaki disease pathology may be influenced by vascular endothelial growth factor gene variations
Large-B-Cell Lymphoma Therapy - Rituximab added to CHOP effective in pediatric good-prognosis diffuse large-B-cell lymphoma
Leukemia - Leukemia patient survival in high-risk group was shorter compared to low-risk group
Leukemia Therapy - Patients with treatment-resistant leukemia achieve high responses to Tasigna (nilotinib) in first published clinical trial results
Liver Transplantation - Acute cellular rejection rates are lower in recipient-donor pairs
Liver Transplantation - Post-transplantation course of hepatitis C is unrelated to calcineurin inhibitor
Lung Cancer - Lung cancer survival not improved with irinotecan and cisplatin versus etoposide and cisplatin
Lung Cancer - Lung cancer treated by irinotecan combined with carboplatin
Lung Cancer - Lung cancer treated by weekly paclitaxel and gemcitabine
Lung Cancer - NSCLC gemcitabine MTD concurrent with thoracic radiotherapy is determined
Lymphoma - Diffuse large cell lymphoma outcome not influenced by minimal bone marrow involvement
Market Analysis - Report suggests drug discovery and development can be done easier and better in India
Medical Devices - Atrial septal defects of small-to-moderate diameter are best for closure with Helex septal occluder
Medullary Thyroid Cancer - Medullary thyroid carcinoma prognosis linked to disseminated tumor cells in the connective tissue
Melanoma - Medarex gets U.S. FDA SPA to initiate registration trial of ipilimumab in melanoma patients
Mesothelioma - CuraGen and TopoTarget initiate Phase II clinical trial with PXD101 for mesothelioma
Migraines - Botox reduces frequency of migraines for chronic sufferers
Multiple Myeloma - Bortezomib for injection shows positive results in newly diagnosed multiple myeloma patients
Multiple Sclerosis - Copaxone reduced relapses by 75% in trial of multiple sclerosis patients
Natural Products - Gynostemma pentaphyllum is an effective adjunct treatment to diet
Natural Products - Cancer treatment by natural plant products warrants clinical trial
Neuroscience - Serotonin transporter protein polymorphism influences migraine without aura
Obstetrics - Genital tract trauma may be reduced by use of controlled delivery techniques
Obstetrics - Shorter labor duration was observed in women given increased intravenous fluids
Oral Health - Oragenics to enter clinic with oral probiotic mouthrinse
Osteoarthritis - Intraarticular steroid treatment provides significant benefits for patients with hip osteoarthritis
Ovarian Cancer - Morphotek granted orphan drug status for monoclonal antibody for ovarian cancer treatment
Ovarian Cancer - Ovarian cancer chemotherapy-associated PPE may be reduced with PLD
Pancreatic Cancer - ArQule initiates phase II trial of ARQ 501 for pancreatic cancer
Papillary Microcarcinoma - Clinically overt and occult papillary microcarcinoma should be differentiated
Parkinson Disease - Testosterone therapy may benefit men with Parkinson disease
Paroxysmal Nocturnal Hemoglobinuria - Alexion launches EXPLORE study for severe anemia disorder
Pediatric Anesthesia - Children during anesthesia can maintain core temperatures with a convection heater
Personnel - SFBC International reports resignation of Gregory B. Holmes after Florida operations close
Prostate Cancer - Acapodene lowered LDL, raised HDL in prostate cancer patients on androgen deprivation therapy
Prostate Cancer - GM-CSF modulates PSA in androgen dependent, biochemically relapsed prostate cancer
Prostate Cancer - Prostate cancer risk could be linked to hypercholesterolemia
Prostate Cancer - Prostate cancer risk increased by CYP1A1, p53, GSTM1 polymorphisms and smoking
Prostate Cancer Vaccine - Peptide cocktail-loaded dendritic cells show some promise for hormone-refractory prostate cancer
Radiation Dermatitis - Radiation dermatitis in head and neck cancer patients not improved by trolamine
Rectal Cancer - Rectal cancer that invades reproductive organs could only be cured by posterior pelvic exenteration
Relapsing Remitting Multiple Sclerosis - Antisense Therapeutics commences dosing of patients in Phase IIa multiple sclerosis trial
Renal Transplantation - Transplantation may modify hepatitis C virus infection
Rheumatoid Arthritis - Genmab presents AMG 714 phase II results at rheumatism conference
Rheumatoid Arthritis - HAQ responsiveness is inversely associated with mean duration of RA in clinical trials
Sleep Disorders - Sepracor presents Lunesta poster data at Associated Professional Sleep Societies meeting
Spinal Muscular Atrophy - Epilepsy drug eases symptoms of adult spinal muscular atrophy
Spine Surgery - Reoperation incidences after lumbar TDR with the Charite Artificial Disc are assessed
Statins - Statins inhibit platelet PAR-1 thrombin receptor in metabolic syndrome patients
Stroke - Ischemic stroke interactive associations clarified
Surgical Technology - Robot-assisted versus laparoscopic Nissen fundoplication is studied
Thyroid Cancer - Thyroid cancer risk increased in Filipino patients with thyroid nodules
Varicose Veins - BTG to commence U.S. phase II safety study of Varisolve for varicose veins
Astrocytomas - Researchers from Japan, the United States and Sweden describe findings in astrocytomas studies
Brain Cancer - Researchers from Germany, the United States and Finland publish new studies and findings in the area of brain cancer
Breast Cancer - New findings from the United States in the area of breast cancer described
Breast Cancer - Researchers from the United Kingdom, Canada and Germany report details of new studies and findings in the area of breast cancer
Breast Cancer - Researchers from the United States provide details of new studies and findings in the area of breast cancer
Breast Cancer - Researchers' data from Scotland and the United Kingdom advance breast cancer research
Breast Cancer - Studies from Netherlands, Germany and United Kingdom add new findings to breast cancer body of knowledge
Breast Cancer - Studies from Switzerland describe new findings in breast cancer research
Cancer Treatment - Researchers' work from the United States adds to cancer treatment body of knowledge
Cardiology - Findings from the United States advance knowledge in cardiology research
Cell Biology - Studies from the United States and Germany describe new findings in cell biology research
Clinical Trials - Studies from the United States add new findings to clinical trials body of knowledge
Colorectal Cancer - Recent findings in colorectal cancer described by researchers from Greece, Argentina and Canada
Contraception - Researchers from Brazil, the United States and Norway report recent findings in contraception
Diabetes - Findings from Australia, Belgium and Netherlands describe new data in diabetes research
Environmental - Studies from Canada, the People's Republic of China and the United Kingdom add new findings to environmental body of knowledge
Gastrointestinal Stromal Tumor - Researchers from Poland, Germany and France detail new studies and findings in the area of gastrointestinal stromal tumor
Heart Attack - Studies from Japan and the New Zealand add new findings to heart attack body of knowledge
Hepatitis B Virus - New findings from India, the People's Republic of China and the United States in the area of hepatitis B virus described
Hepatitis B Virus - Recent findings in hepatitis B virus described by researchers from Taiwan, Japan and the People's Republic of China
Hepatitis B Virus - Studies from the People's Republic of China, Netherlands and Greece describe new findings in hepatitis B virus research
Hepatitis C Virus - Findings from the United States, Taiwan and Germany describe new data in hepatitis C virus research
Hepatocellular Carcinoma - Data from Sweden and Japan advance knowledge in hepatocellular carcinoma research
Liver Diseases - Reports from the United States, Germany and Japan advance knowledge in liver diseases research
Lung Cancer - Findings from Taiwan, Japan and the United States advance knowledge in lung cancer research
Lung Cancer - Reports from Spain, Greece and Italy add new data to lung cancer research
Lung Cancer - Researchers from South Korea and United States report recent findings in lung cancer
Meningitis - Data from the United Kingdom and Italy advance knowledge in meningitis research
Mesothelioma - Researchers' work from Belgium, the United Kingdom and the United States adds to mesothelioma body of knowledge
Osteoporosis - Researchers from Belgium, Denmark and Australia provide details of new studies and findings in the area of osteoporosis
Osteoporosis - Researchers from the Australia 6009; rlprince@cyllene, Japan and Italy report recent findings in osteoporosis
Papillomavirus - Researchers from Finland, Belgium and the United States report details of new studies and findings in the area of papillomavirus
Polycystic Ovarian Syndrome - Researchers from the United States, Brazil and United Kingdom detail new studies and findings in the area of polycystic ovarian syndrome
Prostate Cancer - Studies from the United States, Japan and Italy advance knowledge in prostate cancer research
Rectal Cancer - Researchers from South Korea, Taiwan and Italy detail new studies and findings in the area of rectal cancer
Renal Cancer - Researchers from Japan, Italy and Germany describe findings in renal cancer studies
Thromboembolism - Reports from the United States and France describe recent advances in thromboembolism research
Vaccines - Recent findings in vaccines described by researchers from Germany, Taiwan and the United States
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