Clinical Trials Week

Breast Cancer - Raloxifen reduces breast cancer risk with lower incidence of thromboembolic events

Colorectal Cancer - Colorectal carcinogenesis linked to dietary iron levels

Drug Development - DanioLabs starts clinical trial with new treatments for Parkinson disease symptoms

Gastroenterology -  Lactobacillus and Bifidobacterium combination is effective for diarrhea therapy

Pain Management - Valdecoxib is effective for treating pain due to acute ankle sprain

Acute Myeloid Leukemia - New survival data on Evoltra (clofarabine) in elderly leukemia patients reported

Age-Related Macular Degeneration - Choroidal neovascular membranes show an early response to photodynamic therapy

Age-Related Macular Degeneration - Patients with neovascular age-related macular degeneration have favorable reactions to pegaptanib

Alzheimer Disease - Risk for Alzheimer disease is not associated with vascular endothelial growth factor genotypes

Amyotrophic Lateral Sclerosis - Avicena initiates phase II study of combination therapies for amyotrophic lateral sclerosis

Angiology & Obesity - Sibutramine therapy is associated with weight loss and improved endothelial function

Aortic Aneurysms - Stent grafts being investigated as minimally invasive treatment for thoracic aortic aneurysms

Asthma - Asthma airways exhibit disproportionate angiogenesis

Asthma - Asthma patients chase symptoms rather than preventing the underlying disease

Avian Influenza - Baxter initiates study with cell-based candidate H5N1 pandemic vaccine

Avian Influenza - PowderMed submits regulatory documentation to conduct a clinical trial of a bird flu vaccine

Benign Prostate Hyperplasia - Nymox reports update on multicenter trial of benign prostatic hyperplasia drug

Bipolar Disorder - SSRIs act as mood stabilizers for bipolar II disorder

Bladder Cancer - Bladder cancer growth inhibited by quercetin

Bladder Cancer - Bladder cancer risk association with APE1 genotype evaluated in smokers and nonsmokers

Bladder Cancer - Chemoprevention trials should consider higher dose of 4-HPR

Breast Cancer - Breast cancer chemoprevention reviewed

Breast Cancer - Breast cancer progression influenced by integrin alpha-2 and beta-3 gene polymorphisms

Breast Cancer - Hereditary and sporadic breast cancers are differentiated with decision tree analysis

Business & Finance - Javelin Pharmaceuticals wins phase II small business innovation research grant

Business Update - Covalent Group amends business combination agreement with Remedium Oy

Business Update - DATATRAK to receive five cardiac safety projects from COResearch relationship

Business Update - DOR BioPharma announces successful completion of cGMP production milestone for RiVax

Business Update - DOR BioPharma provides regulatory update on orBec

Business Update - ICON enhances presence in Eastern Europe with new offices in Poland and Lithuania

Cancer Risk Factors - Multi-organ cancer risk linked to A148T variant in Polish population

Cancer Therapy - Disease stability is observed in cancer patients treated with antiangiogenic peptide

Cancer Therapy - Pain associated with bone metastasis in prostate cancer patients reduced with zoledronic acid

Cancer Therapy - Phase I dose escalation study of pegylated liposomal doxorubicin with topotecan is conducted

Cancer Vaccine - Epeius Biotechnologies initiates Tri-REX Vaccination Protocols for breast cancer

Capnography - Patient monitoring during moderate sedation is improved with microstream capnography

Cardiac Medical Devices - U.S. FDA approves start of clinical trials for Topspin Medical's intravascular MRI catheter

Cardiac Medical Devices - WorldHeart reports implanted rotary ventricular assist device explanted, patient released

Cardiology - Tricuspid regurgitation is effectively corrected with a remodeling prosthetic ring

Cardiopulmonary Resuscitation - Inspired oxygen concentrations in early post-resuscitation period are compared

Cardiovascular Research - Clinical trials will test life-saving interventions for critical trauma and sudden cardiac arrest

Central Nervous System Tumors - Survivors of central nervous system tumors had reduced risk for leaving home

Cerebral Palsy - Reporting quality of cerebral palsy clinical trials needs improvement

Cesarean Section - Postoperative pain following cesarean section is not reduced by magnesium sulfate therapy

Chronic Angina - CV Therapeutics' MERLIN TIMI-36 study to continue as planned

Clinical Trials - Arbios Systems announces that UCSF will serve as additional site for SEPET clinical trial

Clinical Trials - Atrial fibrillation is converted to sinus rhythm with moderate effectiveness by pilsicainide

Clinical Trials - Early revascularization in acute MI complicated by cardiogenic shock is recommended

Clinical Trials - NuVasive announces IDE approval to begin NeoDisc pivotal trial

Clinical Trials - Paroxysmal atrial fibrillation recurrence is more effectively prevented with cibenzoline

Clinical Trials - U.S. FDA, ACRO, and CDISC announce new standards project to streamline clinical trial process

Collaborations - Abbott, AstraZeneca partner to develop and commercialize Crestor, TriCor combination

Collaborations - Vertex, Tibotec announce plans for initiative to increase awareness of hepatitis C

Colorectal Cancer - Colorectal cancer etiology linked to vitamin D and sunshine exposure

Colorectal Cancer - Colorectal cancer location at fold-top may reduce risk of lymph node metastasis

Colorectal Cancer - Colorectal cancer patients treated by S-1 combined with irinotecan

Colorectal Cancer - Colorectal cancer risk in Taiwanese males linked to cyclin D1 A870G polymorphism

Dental Research - Mandibular implant-supported overdentures fitted with different attachment types compared

Diabetes & Obesity - Metformin improved body composition and fasting insulin in obese insulin-resistant children

Diabetes Complications - Diuretics and beta-blockers may accelerate type 2 diabetes development in hypertension

Diabetes Therapy - Basal insulin plus oral drug therapy achieves guideline-recommended HbA_1c values

Diabetes Therapy - New study shows cinnamon extract lowers blood sugar levels in people with type 2 diabetes

Diabetes Therapy - Urinary N-acetyl-Ser-Asp-Lys-Pro may be a biomarker for assessing ACE inhibition therapies

Drug Delivery - pSivida files U.K. patent application for drug delivery platform that can act as adjuvant

Drug Development - Acologix' AC-100 forms new dentin in phase II trial

Drug Development - EPIX Pharmaceuticals files appeal with FDA regarding Vasovist Approvable Letters

Drug Development - Hana Biosciences submits Zensana (ondansetron HCl) Oral Spray NDA to U.S. FDA

Drug Development - NicOx announces patient enrollment ongoing in NCX 1000 phase 2 study

Drug Efficacy - Beta-blockers in older hypertensive patients should not be first-line therapy

Drug Safety - MultiHance is well-tolerated in children and adults with CAD or impaired renal or kidney function

Emergency Medicine - Cardiopulmonary resuscitation outcome is better with manual CPR

Esophageal Cancer - Esophageal cancer tumor response and shape change measurements discussed

Follicular Lymphoma - Follicular lymphoma patient age should not be a contraindication for aggressive chemotherapy

General Anxiety Disorder - Abiogen's initiates phase II trial in Vienna for new anti-anxiety drug

Glioblastoma - Glioblastoma functional outcome improved via navigation-guided fence-post procedure

HIV/AIDS Prevention - Randomized trials needed to determine whether adult male circumcision reduces HIV risk

HIV/AIDS Therapy - HIV-infected women show improvement in physical fitness measures through exercise program

HIV/AIDS Therapy - Prezista receives U.S. FDA approval as part of HIV combination therapy

Head & Neck Cancer - The response of oral cancer to carboplatin is predicted by blood vessel density

Healthcare Costs - Non-health care and time cost data regarding cancer was collected

Heart Disease - CardioVascular BioTherapeutics cofounder discusses new therapy for heart disease

Hepatitis B Virus - Chronic hepatitis B can be treated using entecavir