Clinical Trials Week
Susan Hasty, Publisher
Table of Contents . . . September 18th, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Clinical Trials Week | Other Publications
Clinical Trials - Sirolimus-eluting stents at 2 years post-implantation demonstrate sustained efficacy, safety
Colorectal Cancer - Colorectal cancer risk reduced due to nonsmoking and NSAID use
Diabetes Therapy - Pioglitazone improves glycemic control and atherosclerosis risk factors in type 2 diabetes
Lymphoma - CuraGen and TopoTarget announce Southwest Oncology Group opens new lymphoma trial with PXD101
Menopause - Menopause symptoms are not affected by ingestion of soy flour and dietary flaxseed
Adverse Drug Reaction - Onercept evaluated for use in moderate-to-severe Crohn's disease
Age-Related Macular Degeneration - Athenagen initiates development of anti-angiogenic eye drop therapy for vision loss
Age-Related Macular Degeneration - Neovascular age-related macular degeneration risk is reduced by hormone therapy
Alzheimer Disease - Enrollment complete in U.S. trial of selective amyloid lowering drug for Alzheimer disease
Asthma - AIR2 trial begins at Baptist Hospital West
Asthma - Critical Therapeutics announces results of Phase I/II trial of intravenous formulation of Zileuton
Asthma - Sputum from asthma patients contains excess levels of angiogenesis regulators
Attention Deficit Hyperactivity Disorder - ADHD medication use affected by comorbidity and family history of treatment
Atypical Spitz Tumors - Atypical Spitz tumor clinicopathologic findings discussed
Avian Influenza - University of Pittsburgh receives $1.3 million from the U.S. National Institutes of Health to develop bird flu vaccine
Bladder Cancer - Bladder cancer possibly linked to polymorphism in TNF-beta gene in Japanese patients
Breast Cancer - Breast cancer outcomes are predicted by cells linked to tumor angiogenesis
Breast Cancer - Breast cancer patient stay shortened with axillary padding after lymphadenectomy without a drain
Breast Cancer - Breast cancer patients with BRCA1/2 mutations have unique histopathology
Breast Cancer - Breast cancer patients' renal function not affected by intravenous ibandronate
Breast Cancer - Breast cancer postoperative seroma not prevented with fibrin sealant
Breast Cancer - Quality of life for breast cancer survivors is improved by aerobic and resistance training
Business & Finance - Diversified business portfolio helps Medtronic report strong first quarter earnings per share
Business Update - BioMag granted permission from Mexican government to conduct clinical trials
Business Update - BioSyntech receives approval for Canadian BST-DermOn pivotal clinical trial
Business Update - CardioVascular BioTherapeutics co-founder presents seminar on potential new heart disease treatment
Business Update - CoGenesys announces worldwide license agreement with Vegenics Limited
Business Update - Four studies affirm significance of Monogram's Trofile HIV co-receptor tropism assay
Business Update - GenVec vaccine technology enters first HIV human clinical trials at Vaccine Research Center at NIH
Business Update - SyntheMed receives CE Mark approval for bioabsorbable adhesion barrier for cardiac surgery
Business Update - Thoratec and Levitronix announce U.S. co-distribution agreement for Levitronix CentriMag System
Business Update - US Oncology, Molecular Profiling form venture to speed personalized cancer treatment efforts
Cancer Gene Therapy - Pharmacokinetics of oncolytic measles virotherapy clarified
Cancer Therapy - Celldex Therapeutics presents new EGFRvIII expression and clinical data at summit
Cancer Therapy - Glioma management by convection-enhanced delivery discussed
Cancer Therapy - Oncolytics Biotech completes enrollment in U.S. Phase I clinical trial
Cancer Therapy - Xyotax, radiation produces responses in 91 percent of esophageal, gastric cancers
Cardiopulmonary Resuscitation - Thrombolytic agents improve outcome for patients treated with cardiopulmonary resuscitation
Cardiovascular Disease - Altered lipid metabolism in women with polycystic ovary syndrome may indicate heart disease risk
Clinical Trials - Cardiovascular risk factors are improved by Mediterranean diets supplemented with olive oil or nuts
Clinical Trials - NEDO biventricular assist device development program is reviewed
Clinical Trials - New block of clinical trials standardized on Datatrak platform
Clinical Trials - Paclitaxel-eluting stent cost effectiveness is described for patients undergoing PCI
Clinical Trials - Pharmaceutical industry increases investigator-initiated trial spending by 42%
Collaborations - GammaCan International and Life Therapeutics announce a signed Term Sheet for developing VitiGam
Colon Cancer - Colon cancer prognosticated by histologic type of primary lesion and metastatic lymph nodes
Colorectal Cancer - Colorectal cancer linked to microsatellite GT polymorphism in toll-like receptor 2
Colorectal Cancer - Colorectal micropapillary carcinoma identified as aggressive variant of adenocarcinoma
Dermatology - Atopic dermatitis linked to increased macrophage migration inhibitory factor
Dermatology - EFoodSafety.com Inc. reports completion of clinical trials on scar cream
Diabetes Pathogenesis - Genetic factors for type 2 diabetes mellitus assessed
Diabetes Therapy - Akesis cites new study demonstrating positive effects of chromium/sulfonylurea in type 2 diabetes
Diagnostics - Diagnosis of peanut allergy results from recombinant allergens skin prick test
Diet & Nutrition - Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure
Drug Development - Cytokinetics announces initiation of Phase I clinical trial for oral administration of CK-1827452
Drug Development - Kosan names its lead Hsp90 inhibitor compounds KOS-953 and KOS-1022
Drug Development - Laureate Pharma to produce Lpath's Sphingomab for phase I clinical trials
Drug Development - Neuren announces favorable Phase 2a pharmacokinetic and safety data for Glypromate
Drug Safety - Statin hepatotoxicity is not significant in the treatment of hepatitis C
Epidemiology - Identifying causes of cardiac death is process of limited reliability and accuracy
Gastroenterology - Gastric cancer's link to P53 codon 72 polymorphisms investigated
Gastroenterology - Gastrointestinal cancer postoperative outcome improved by preoperative enteral immunonutrition
Gastroenterology - Wyeth, Progenics initiate phase 2 trial of methylnaltrexone for opioid-induced constipation
Glioblastoma - Glioblastoma linked to increased concentrations of transforming growth factor beta 2
Glioblastoma - Glioblastoma patients demonstrate the safety of cannabinoid therapy
HIV/AIDS Anemia - Maternal and neonatal vitamin A supplementation does not affect hemoglobin or anemia
HIV/AIDS Research - Study results of two-drug regimen show sustained viral suppression in treated HIV patients
HIV/AIDS Vaccine - Vical initiates trial of prime-boost vaccine for disease prevention in HIV-infected patients
Hematologic Cancer - Piperacillin-tazobactam effective for febrile neutropenia in hematologic cancer
Hepatitis C Virus - Co-infection involving hepatitis C does not influence viral clearance
Hepatitis C Virus - Hepatitis C in HIV-coinfected patients responds to combination therapy
Hepatitis C Virus - Hepatitis C virus infection is cleared more efficiently in females
Hepatitis C Virus - Hepatitis C virus-specific CD8 cell costimulation is impaired by HIV coinfection
Herpes Labialis Treatment - Cold sores effectively treated with single-dose topical iontophoresis of acyclovir
Imaging - Radiology outsourcing in India breaks new ground
Immunosuppressive Therapy - Isotechnika announces promising results from phase I TAFA93 trials
Immunotherapy - Granulocyte macrophage colony stimulating factor is a promising therapy for autoimmune lung disease
Inflammatory Bowel Disease - Antibodies could contribute to the prothrombotic state of inflammatory bowel disease
Lung Cancer - Lung adenocarcinoma risk linked to single nucleotide polymorphism at codon 133 of RASSF1 gene
Lung Cancer - Lung cancer patients are at risk for nocturnal sleep disturbance and daytime sleepiness
Lung Cancer - Lung carcinogenesis due to occupational silica exposure remains unclear
Malaria Therapy - Intermittent preventive malaria treatment was moderately successful in Mozambican infants
Medical Devices - Dual chamber ICD performance is not adversely affected by advanced atrial detection
Melanoma - Delcath Systems announces a new site for the Phase III Doxorubicin clinical trial
Mergers & Acquisitions - Genzyme to initiate tender offer to acquire AnorMED, Inc.
Migraine Therapy - Sumatriptan acutely increases aortic blood pressure, stiffness, and augmentation index
Non-Hodgkin Lymphoma - Non-Hodgkin lymphoma risk not linked to mutation of 5'-flanking region of BCL6
Obesity Therapy - Sitagliptin improved dipeptidyl peptidose-IV activity and glucagons-like peptide-1 in obese
Obstetrics - Pre-pregnancy obesity and excess weight gain during pregnancy increase rates of macrosomia
Oncology - Cancer risk may be associated with atopy and atopy-related diseases
Ophthalmology - Eye surgeries prove safe when offered sequentially or when combined
Otorhinolaryngology - Tracheoesophageal voice restoration with a custom-fit prosthesis treats leakage
Ovarian Cancer - Childhood ovarian cancer survivors have increased future risk of premature menopause
Ovarian Cancer - Ovarian cancer patients benefit from tailored decision aid about cancer risk management
Pancreatic Cancer - Pancreatic neoplasia was more frequent in high-risk individuals with EUS and ERCP abnormalities
Parkinson Disease - Alendronate + vitamin D2 therapy reduces hip fractures in women with Parkinson disease
Patents - U.S. patent issued for methods of treatment, formulations for oral rheumatoid arthritis drug
Periodontal Disease - Periodontal disease does not involve a specific gene polymorphism
Prostate Cancer - Dendreon submits clinical and non-clinical sections of rolling BLA to U.S. FDA for Provenge
Quality of Life - Recommendations for assessing quality of life in surgical oncology trials listed
Rectal Cancer - Rectal cancer treated with oxaliplatin plus 5-fluorouracil and preoperative chemoradiation
Retinopathy - Eyes with central retinal vein occlusions treated with lamina puncture maintain vision loss
Rheumatoid Arthritis - Kemia completes successful phase I trials for oral anti-inflammatory drug KC706
Spinal Cord Injury - BioAxone reports patients complete 6-week follow-up in phase I/IIa trial of Cethrin
Statins - Blood pressure in MI survivors without hypercholesterolemia was not reduced by pravastatin
Stem Cell Research - Autologous stem cell transplantation predicted by cell number in blood
Stroke - Neurobiological Technologies selects sites for Viprinex Phase III trial for stroke
Thyroid Cancer - Thyroid carcinoma risk linked to glutathione S-transferase polymorphisms
Type 2 Diabetes - Depomed and King Pharmaceuticals prepare for launch of Glumetza
Angiology - Findings from China, Japan and Italy advance knowledge in angiology research
Angiology - Reports from the United Kingdom, Austria and Canada advance knowledge in angiology research
Breast Cancer - New findings from the United Kingdom and United States in the area of breast cancer detailed
Breast Cancer - Studies from the United States, Japan and Scotland describe new findings in breast cancer research
Cancer Treatment - New findings from the United Kingdom, People's Republic of China and United States in the area of cancer treatment detailed
Cancer Treatment - New findings from the United States, United Kingdom and People's Republic of China in the area of cancer treatment described
Cancer Treatment - Researchers from the United States and Turkey publish new studies and findings in the area of cancer treatment
Cervical Cancer - Researchers from the Canada H2W 1S6; eduardo, Spain and United States provide details of new studies and findings in the area of cervical cancer
Colorectal Cancer - Findings from Taiwan, Turkey and the United Kingdom in colorectal cancer provide new insights
Colorectal Cancer - Researchers from Japan, France and the United Kingdom report recent findings in colorectal cancer
Diabetes - Researchers' work from the United States and Brazil adds to diabetes body of knowledge
Diagnostics - Research from the United States, France and Italy add new data to diagnostics body of knowledge
Diet & Nutrition - New research from South Africa, Sweden and New Zealand in the area of diet & nutrition detailed
HIV/AIDS - Researchers from the United States detail new studies and findings in the area of HIV/AIDS
HIV/AIDS - Studies from the United States add new findings to HIV/AIDS body of knowledge
Hepatitis B Virus - Researchers' data from Taiwan, Canada and Japan advance hepatitis B virus research
Hepatitis B Virus - Studies from Italy and the South Korea advance knowledge in hepatitis B virus research
Hepatitis C Virus - Findings from Switzerland, France and the United States describe new data in hepatitis C virus research
Hepatitis C Virus - Recent findings from South Africa, Canada and United States illuminate research in hepatitis C virus
Hepatocellular Carcinoma - Research from the People's Republic of China and Italy in hepatocellular carcinoma provides new insights
Hypertension - Findings from the United States, France and Japan advance knowledge in hypertension research
Influenza - Recent studies from the United States and United Kingdom add new data to influenza research
Leukemia - Recent findings in leukemia described by researchers from the United States and Norway
Lung Cancer - Findings from Canada, Greece and the United States in lung cancer provide new insights
Lung Cancer - Findings from Japan, the People's Republic of China and Denmark describe new data in lung cancer research
Lung Cancer - Findings from the United States and Belgium describe new data in lung cancer research
Lung Cancer - New research from Germany and Japan in the area of lung cancer detailed
Lung Cancer - Recent findings in lung cancer described by researchers from Taiwan and Japan
Lung Cancer - Recent findings in lung cancer described by researchers from the United States and Spain
Lung Cancer - Researchers from Norway, Austria and Taiwan provide details of new studies and findings in the area of lung cancer
Lung Cancer - Studies from Japan, Germany and Canada advance knowledge in lung cancer research
Lymphoma - Data from Israel, Norway and the United Kingdom advance knowledge in lymphoma research
Neurology - New findings in neurology described from Japan and Australia
Obesity - Researchers' work from the United States adds to obesity body of knowledge
Osteoporosis - Findings from the United States describe new data in osteoporosis research
Osteoporosis - New data from France, the United States and Belgium lluminates research in osteoporosis
Osteoporosis - New findings in osteoporosis described from New Zealand and United States
Osteoporosis - Recent findings in osteoporosis described by researchers from Austria, the United States and Japan
Prostate Cancer - Recent studies from the United States add new data to prostate cancer research
Prostate Cancer - Researchers from the People's Republic of China, Chile and Canada report recent findings in prostate cancer
Prostate Cancer - Researchers from the United States and Canada describe findings in prostate cancer studies
Rectal Cancer - Recent studies from Italy and Denmark add new data to rectal cancer research
Renal Cancer - Data from the United States, Germany and Japan advance knowledge in renal cancer research
Surgery - New findings in surgery described from Germany, the United States and Austria
Transplants - Reports from the United States, Brazil and Germany advance knowledge in transplants research
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