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Atrial fibrillation incidence in chronic heart failure patients is reduced with candesartan

Published in Clinical Trials Week, September 25th, 2006

Treatment with the angiotensin receptor blocker candesartan reduced the incidence of atrial fibrillation in a large, broadly-based, population of patients with symptomatic chronic heart failure.

Investigators working in Canada noted, "Atrial fibrillation (AF) is frequent in patients with chronic heart failure (CHF). Experimental and small patient studies have demonstrated that blocking the renin-angiotensin-aldosterone system may prevent AF."

"In the CHARM program," explained A. Ducharme and colleagues at the Montreal Heart Institute, "the effects of the angiotensin receptor blocker candesartan on cardiovascular mortality and morbidity were evaluated...

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