Clinical Trials Week
Susan Hasty, Publisher
Table of Contents . . . October 2nd, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Clinical Trials Week | Other Publications
Breast Cancer - Anastrozole is effective and has lower rate of adverse events compared to tamoxifen
Clinical Trials - Ace BioSciences' vaccine for diarrhea caused by Campylobacter enters phase I trials
Complementary & Alternative Medicine - Dai-kenchu-to improved stasis of patients with total gastrectomy and jejunal pouch interposition
Migraines - MAP Pharmaceuticals initiates phase 2 clinical trial in patients with migraine
Age-Related Macular Degeneration - Patients with age-related macular degeneration manifest heart disease indicators
Anemia - Advanced Magnetics completes enrollment in two phase III studies of Ferumoxytol for anemia
Anesthesia - Neuromuscular block at constant levels is achieved with a closed-loop controller
Angiology - Protected carotid stenting in high-surgical-risk patients is safe and effective
Antibacterial Agents - Moxifloxacin is effective treatment for complicated intra-abdominal infections
Assisted Reproduction - Letrozole may be comparable, cost-effective option for intrauterine insemination
Avian Influenza - Sinovac reports Lancet publication of trial results on pandemic influenza vaccine
Behavioral Medicine - Lexicon Genetics initiates phase I trial of LX6171 for cognitive disorders
Bipolar Disorder - Memory Pharmaceuticals starts dosing in trial of calcium channel blocker in bipolar disorder
Brain Cancer - Childhood brain tumor risk could be linked to parental heat exposure
Brain Injury - U.S. Army to conduct trial of peptide drug to reduce brain injury due to cardiac arrest
Breast Cancer - Abraxis provides update on U.S. FDA panel's recommendation for Abraxane trial design
Breast Cancer - Breast cancer diminished survival correlates with topoisomerase expression
Breast Cancer - Breast cancer grade and outcome predicted by KIF14 mRNA expression
Breast Cancer - Introgen's Advexin therapy shows promise in the treatment of breast cancer
Business & Finance - Progen's financial year ends with a positive outlook for 2007
Business Update - Aida Pharmaceuticals provides update on Rh-Apo2L in lymphoma
Business Update - AtCor signs $1.48 million agreement to supply blood pressure measuring system, trial support
Business Update - Curis opts out of co-development of basal cell carcinoma drug candidate
Business Update - Elite receives approval to initiate Phase II clinical trial for abuse-resistant drug product
Business Update - Endovasc announces completion of Liprostin manufacturing for Phase IIIa trial
Business Update - Scios selects Duke research institute to lead outcomes trial of nesiritide in heart failure
Cancer Research - National Cancer Institute awards Cleveland BioLabs contract to development radioprotectors
Cancer Therapy - Treatment shows combination therapy leads to long-term remission in follicular non-Hodgkin's lymphoma
Cardiac Medical Devices - Data suggest CYPHR Sirolimus-eluting Coronary Stent compares favorably to bare metal stents
Cardiac Medical Devices - Trial follow-up data show positive outcomes at 4 years for paclitaxel-eluting stent system
Cardiac Medical Devices - Two-year data suggest Cypher, Taxus stents have different blood clot and heart attack rates
Cardiology - Atrial septal defect closure devices are optimized for closure rates
Cardiology - Azimilide-associated torsades de pointes ventricular tachycardia is characterized
Cardiology - Modified AT-101 motion platform device superior to mechanical closed chest massage device
Cardiology - Nuvelo completes enrollment in Phase III trial of alfimeprase in acute arterial occlusion
Cardiology - Preoperative statin therapy is associated with reduced cardiac mortality
Cardiology - Recombinant factor VIIa use in cardiac surgery produces no adverse effects
Cardiology - SyntheMed announces positive trial results for REPEL-CV in neonatal heart surgery patients
Cervical Cancer - Cervical carcinoma treated by concurrent cisplatin and radiotherapy
Chronic Obstructive Pulmonary Disease - Sepracor presents phase III arformoterol data for bronchitis, emphysema at meeting in Europe
Clinical Trials - ACE inhibitors in stable vascular disease reduce serious vascular events
Clinical Trials - Advanced heart failure patients with renal insufficiency may benefit from adjunctive nesiritide
Clinical Trials - Atrial fibrillation in elderly after on-pump CABG is reduced by prophylactic bisoprolol plus Mg
Clinical Trials - Cardiovascular disease clinical trials' efficacy and safety are discussed
Clinical Trials - EpiCept announces results of European Phase III trial for LidoPAIN SP
Clinical Trials - Lipid-lowering therapy and LDL-cholesterol targets are reviewed in update of clinical trial data
Clinical Trials - Nuvelo completes enrollment in trial of alfimeprase in central venous catheter occlusion
Clinical Trials - Ranolazine + amlodipine treatment of stable coronary patients reduces angina frequency
Clinical Trials - St. Jude statisticians describe new method of analyzing clinical trial results
Clinical Trials - U.S. clinical researchers resist full financial disclosure
Collaborations - Ipsen and GTx enter into partnership agreement for the European Acapodene rights
Collaborations - Santhera, Juvantia to collaborate on developing product for dyskinesia in Parkinson disease
Colon Cancer - Colon cancer survival could be extended with physical activity
Colorectal Cancer - Colorectal cancer treatment with nadroparin was safer than enoxaparin in terms of bleeding risk
Colorectal Cancer - Metastatic colorectal cancer response to chronomodulated FOLFOX predicted by patient gender
Colorectal Surgery - In colorectal surgery, preoperative oral carbohydrate loading reduces hospital stays
Complementary & Alternative Medicine - Japanese herbal medicine effectively prevents headache
Crohn Disease - Abbott submits U.S., E.U. regulatory applications for Humira for Crohn disease
Depression - Depression treatment outcomes are related to early changes in brain function after lead-in
Depression - Escitalopram improves mood and cognitive function in middle-aged women with depression
Developmental Biology - Follicular development can be affected by an oral contraceptive
Diabetes Control - Once-daily oral diabetes treatment Glumetza available
Diabetes Therapy - Type 1 diabetes glucose metabolism affected by recombinant protein
Diabetic Neuropathy - In diabetic neuropathy, no therapeutic difference was seen between oxcarbazepine and placebo
Dialysis - Peritoneal dialysis patients lose peritoneum mast cells
Diet & Nutrition - Hepatocellular carcinoma overall survival not affected after high dose vitamin K3 infusion
Drug Delivery - Boehringer Ingelheim reports asthma, COPD patients are satisfied with soft mist inhaler
Drug Development - Biovertis to start clinical trials for antibiotic agent
Drug Safety - Atomoxetine treatment of ADHD in children seems well tolerated and effective in long term
Dyslipidemia - Liponex initiates dosing for CRD5 clinical trial; patient recruitment is complete
Esophageal Cancer - Esophageal cancer among Turkmen population in Iran linked to familial risk factors
Fibromyalgia - Jazz Pharmaceuticals begins phase III trial to study the safety and efficacy of Xyrem
Finance - Micromet secures $25 million committed equity financing facility from Kingsbridge Capital
Finance - ThermoGenesis Corp. reports Q4 2006 net revenues up 14.8% over year ago to $3,557,000
Gastric Cancer - High gastric cancer en bloc resection rate achieved with endoscopic submucosal dissection
Gastroesophageal Reflux Disease - Addex commences phase II clinical trials program with ADX10059 for acid reflux
Gastroesophageal Reflux Disease - Study demonstrates effectiveness of Plicator procedure to treat GERD
HIV/AIDS HAART - Fosamprenavir-ritonavir similar in safety and efficacy as lopinavir-ritonavir in HIV/AIDS
HIV/AIDS Quality of Life - Spiritual mantram repetition improves quality of life in HIV/AIDS patients
HIV/AIDS Vaccine - AlphaVax reports positive results from alphavaccine phase I trial
HIV/AIDS Vaccine - Virax lodges application to conduct phase 1/2a clinical trial of HIV vaccine in South Africa
Hepatitis B Virus - Fulminant hepatic failure in hepatitis B infection involves caspase activation
Hepatitis B Virus - Hepatitis B virus surface antigen detected by chemiluminescent assay
Hepatitis B Virus - Lamivudine-resistant hepatitis B virus tenofovir therapy described
Hepatitis C Therapy - Bioenvision's Suvus lowers viral load in chronic hepatitis C patients
Hepatitis C Virus - Chronic hepatitis C treatments with peginterferons assessed
Hepatitis C Virus - Chronic hepatitis C virus may involve hepatic progenitor cells
Hepatitis C Virus - Hepatitis B or C infection can prelude cancer
Hepatitis C Virus - Hepatitis C liver persistence is associated with virus-specific T-cell responses
Hepatitis C Virus - Hepatitis C virus RNA can be detected by PCR-based test
Hepatitis C Virus - Hepatitis C virus-positive liver transplant patients may not benefit from treatment withdrawal
Hepatitis C Virus - Iron accumulation in hepatitis C is influenced by Helicobacter pylori
Hepatocellular Carcinoma - Hepatocellular cancer survival extended with frequent local ablation therapy for intrahepatic recurrence
Hereditary Angioedema - Dyax announces update regarding regulatory pathway for DX-88 (ecallantide) in hereditary angioedema
Hypertension - Pooled data analysis confirms efficacy in hypertensive patients treated with renin inhibitor
Immunotherapy - Resistentia reports pioneering results from phase I allergy immunotherapy trial
Interstitial Cystitis - MediciNova completes enrollment in trial of anti-inflammatory drug in interstitial cystitis
Ischemia - Nuvelo Phase II trial results show rNAPc2 has potential to reduce ischemia in ACS
Laryngeal Cancer - Laryngeal cancer treatment guidelines discussed
Leukemia - Leukemia risk in children with Down syndrome linked to household chemical exposure
Leukemia - Pediatric leukemia treated by home-based chemotherapy might be feasible
Licensing Agreements - SurModics and X-Cell Medical sign license agreement for drug eluting stent development
Lipodystrophy - Ark Therapeutics reports initial results of EG005 in HIV-related lipodystrophy study
Lung Cancer - Chinese lung cancer patients who failed previous chemotherapy treated by salvage therapy
Lung Cancer - Elderly lung cancer patients receive new treatment option in docetaxel
Lung Cancer - Lung cancer in elderly responded to carboplatin and irinotecan with G-CSF
Lung Cancer - Lung cancer risk linked to AXIN2 Pro50Ser single nucleotide polymorphism
Lung Cancer - Northwest Biotherapeutics receives clearance for lung cancer trial
Melanoma - Melanoma risk predicted by risk assessment model
Metabolic Syndrome - Oral and transdermal hormone replacement therapies vary in effect on metabolic syndrome factors
Migraines - Minimal headache was evoked by vasoactive intestinal polypeptide in healthy volunteers
Myocardial Infarction - European Commission expands indication for Plavix, offering new option for some heart attacks
Nephrology - Fabry disease-associated renal decline lessened by enzyme replacement therapy
Neuroendocrine Carcinoma - Neuroendocrine carcinoma did not benefit from paclitaxel, carboplatin, and etoposide
Neutropenia - Maxygen initiates phase 1 clinical trial for chemotherapy adjuvant drug for neutropenia
Nosocomial Infections - Phase 2 trial of anti C. difficile antibody combination for hospital acquired diarrhea begun
Obesity Therapy - Low-dose orlistat provides significant weight loss and improves cholesterol levels, data suggest
Obsessive-Compulsive Disorder - Obsessive-compulsive disorder cognitive therapy outcomes are not predicted by treatment motivation
Oral Mucositis - TGR BioSciences commences trial of Lactermin for mouth ulcers
Otorhinolaryngology - Adenotonsillectomy postoperative pain is controlled using rectal drug administration
Otorhinolaryngology - Tonsillectomy using coblation versus unipolar electrocautery is compared
Ovarian Cancer - Addition of topotecan to carboplatin-paclitaxel therapy does not improve survival
Ovarian Cancer - Ovarian cancer had small response to novel chemotherapeutic agent KW-2170
Pancreatic Islets - MRI can track the survival of pancreatic islets after transplantation
Parathyroid & Cardiovascular Disease - Therapeutic strategies for secondary hyperparathyroidism in dialysis patients are focus of review
Personnel - Cubist Pharmaceuticals appoints Gordon L. Archer, MD, to its board of directors
Personnel - Integrium names Richard Caroddo director of business development
Postpartum Depression - Postpartum depression responds similarly to sertraline or nortriptyline therapy
Prognostics - Neoadjuvant chemotherapy response predicted in breast cancer patients
Psoriatic Arthritis - Psoriatic arthritis is linked to peroxisome proliferator-activated receptor-gamma gene polymorphism
Pulmonary Arterial Hypertension - Myogen presents positive ambrisentan phase III data at World Congress of Cardiology
Pulmonary Hypertension - Myogen starts Phase III clinical trial of ambrisentan in pulmonary hypertension
Rectal Cancer - Rectal cancer treatment by fluorouracil-based chemotherapy regimens plus radiotherapy assessed
Respiratory Medicine - Cobalis completes enrollment in twin Phase III clinical trials for PreHistin
Respiratory Medicine - Newborn pulmonary vascular development requires lymphangiogenesis protein
Rotavirus Vaccine - Bovine-human rotavirus reassortant tetravalent vaccine safe and immunogenetic
Sexual & Reproductive Health - Aromatase inhibitors can contribute to normal potential of implantation
Sexual & Reproductive Health - Bone mineral density changes may reverse after discontinuing depot medroxyprogesterone acetate
Sickle Cell Anemia - Sickle cell zinc inversely correlates with adhesion molecule concentration
Spine Surgery - Computer-assisted spine surgery reduces intraoperative radiation doses
Stroke - Stroke models respond to gene therapy that stimulates angiogenesis
Thyroid Cancer - Thyroid cancer risk was high in persons exposed in childhood to I-131 from the Chernobyl accident
Type 2 Diabetes - Actos (pioglitazone HCl) reduces risk of secondary stroke in high-risk type 2 diabetes
Type 2 Diabetes - Amylin reports positive results from study of Symlin in type 2 diabetes control
Angiology - New findings from Spain, India and Italy in the area of angiology described
Antibiotics - Recent findings in antibiotics described by researchers from the United States and France
Breast Cancer - New findings from U, Brazil and Israel in the area of breast cancer detailed
Breast Cancer - Reports from Italy, Turkey and Germany describe recent advances in breast cancer research
Breast Cancer - Researchers from the United States detail new studies and findings in the area of breast cancer
Cancer Treatment - New data from the United States and Sweden lluminates research in cancer treatment
Cancer Treatment - Reports from the United States, People's Republic of China and Japan describe recent advances in cancer treatment research
Cancer Treatment - Researchers from France, the People's Republic of China and the Canada M5G 2M9; Email: amit report details of new studies and findings in the area of cancer treatment
Cancer Treatment - Researchers from Germany, Denmark and Australia provide details of new studies and findings in the area of cancer treatment
Cardiology - New research from the United States and Taiwan in the area of cardiology detailed
Cardiology - Recent findings from Italy, the United States and the People's Republic of China illuminate research in cardiology
Cardiology - Reports from Germany, Australia and Spain describe recent advances in cardiology research
Cervical Cancer - Recent findings from Italy, the United Kingdom and Sweden illuminate research in cervical cancer
Clinical Trials - Studies from the United States, Argentina and Italy advance knowledge in clinical trials research
Colorectal Cancer - Data from Japan and Germany advance knowledge in colorectal cancer research
Colorectal Cancer - Research from Japan and Austria add new data to colorectal cancer body of knowledge
Colorectal Cancer - Studies from South Korea, Japan and Germany add new findings to colorectal cancer body of knowledge
Diabetes - New findings from Netherlands, Austria and Ireland in the area of diabetes detailed
Diabetes - New findings from the United States and United Kingdom in the area of diabetes described
Diabetes - Recent findings in diabetes described by researchers from the United States and Russia
Diabetes - Recent studies from France and the United States add new data to diabetes research
Diabetes - Researchers' data from Italy and Japan advance diabetes research
Endocrinology - Reports from the SERBIA MONTENEG, France and United States add new data to endocrinology research
Endometrial Cancer - Researchers' findings from Canada, docjdmire@yahoo and the United States advance endometrial cancer research
Esophageal Cancer - New research from Belgium, the United States and Japan in the area of esophageal cancer detailed
HIV/AIDS - Researchers' findings from the United States advance HIV/AIDS research
Leukemia - New findings in leukemia described from Germany and the United Kingdom
Leukemia - Reports from Japan, the United Kingdom and France describe recent advances in leukemia research
Lung Cancer - Data from Finland, the South Korea and the United States advance knowledge in lung cancer research
Lung Cancer - New findings from Germany, the United States and Japan in the area of lung cancer described
Lung Cancer - New findings in lung cancer described from the United States, Taiwan and Italy
Lung Cancer - New research from Spain, Canada and the United States in the area of lung cancer detailed
Lung Cancer - Reports from Italy and Greece advance knowledge in lung cancer research
Lung Cancer - Research from the United States and Switzerland add new data to lung cancer body of knowledge
Lung Cancer - Researchers from Italy, France and the United States publish new studies and findings in the area of lung cancer
Melanoma - Reports from the United States advance knowledge in melanoma research
Osteoporosis - Findings from Finland, Denmark and the United States in osteoporosis provide new insights
Otorhinolaryngology - Researchers from Singapore, Canada and the United States describe findings in otorhinolaryngology studies
Prostate Cancer - Findings from Japan and the United States in prostate cancer provide new insights
Prostate Cancer - Researchers from the United States and Sweden provide details of new studies and findings in the area of prostate cancer
Renal Cancer - Researchers' data from Australia, Italy and Germany advance renal cancer research
Urology - Researchers from Australia, Finland and the United Kingdom report recent findings in urology
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