Clinical Trials Week
Susan Hasty, Publisher
Table of Contents . . . October 9th, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Clinical Trials Week | Other Publications
Clinical Trials - Cardiovascular risk factor study will assess the effect of two trans fatty acid dietary sources
Ovarian Cancer - Pegylated liposomal doxorubicin and ifosfamide treatment Phase I study is conducted
Prostate Cancer - EntreMed commences Panzem NCD Phase 2 study in prostate cancer
Pulmonary Hypertension - Myogen initiates phase 3 trial of ambrisentan in patients with pulmonary hypertension
Stroke Therapy - Albumin therapy shows promise for acute ischemic stroke
Acute Bacterial Sinusitis - Oscient announces results of advisory committee meeting for Factive for acute bacterial sinusitis
Aneurysms - Vascular aneurysm syndromes are distinguished by transforming growth factor-beta receptor mutations
Angiology - Arterial stiffness is increased, cerebral blood flow decreased by asymmetric dimethylarginine
Arthritis - NicOx gives full details of naproxcinod Phase III plan in osteoarthritis
Atrial Fibrillation - Cardiome announces positive Phase 2a results for oral RSD1235 in atrial fibrillation
Awards - Fox Chase scientist receives $10.7 million DoD grant for breast cancer treatment research
Blood Clotting - Study showing superior safety profile of Lovenox versus heparin in PCI patients published
Blood Safety - Cerus initiates Phase I clinical trial for Intercept blood system for red blood cells
Brain Cancer - Pediatric brain tumor patients have highly overexpressed apolipoprotein A-II in cerebrospinal fluid
Breast Cancer - Agendia's MammaPrint breast cancer prognosis test validated by international consortium
Breast Cancer - Breast cancer patient therapeutic response monitored by proton MR spectroscopy
Breast Cancer - Elderly women with breast cancer respond favorably to aromatase inhibitors
Breast Disease - Phyllodes tumors of the breast treatment poses a challenge
Business & Finance - Peregrine Pharmaceuticals reports financial results for first quarter 2007
Business Update - China Medical Technologies presents pre-IDE animal test results for the HIFU Therapy System
Business Update - Elite Pharmaceuticals provides update on company's progress and projected milestones
Business Update - Qualia Clinical Services announces opening of Omaha, Nebraska facility
Cancer Therapy - Chemotherapy vs. ovarian ablation has more adverse effect on health-related quality of life
Cancer Therapy - Melanoma specialist shows how Provectus anticancer agent eradicated treatment resistant tumors
Cancer Therapy - Peregrine initiates bavituximab combination therapy trial in India
Cardiology - Bileaflet heart valve-associated single beat regurgitation is investigated
Cardiology - Can measures of disease progression serve as foundation for therapeutic development?
Cardiovascular Disease - Systolic BP was blunted during exercise in exertional hypertension with losartan, HCTZ
Cardiovascular Research - Study confirms TB4 improves cardiovascular function after heart attack
Chronic Heart Failure - Starting heart failure treatment with bisoprolol reduces sudden death rate 46% after a year
Clinical Trials - Cardiovascular outcomes trials show significant benefit of high-dose vs. standard-dose statins
Clinical Trials - Clinical trials of drug-eluting stents for in-stent restenosis prevention are reviewed
Clinical Trials - Diastolic heart failure morbidity and mortality show no effect from digoxin
Clinical Trials - Ortec announces positive results in confirmatory venous leg ulcer trial
Clinical Trials - Quality of reporting randomized controlled trials in cardiothoracic surgery is suboptimal
Clinical Trials - Radial artery spasm during PCI is prevented by vasodilator administration
Collaborations - Ace, U.S. Naval Medical Research partner to move Campylobacter vaccine through phase II
Collaborations - CardioVascular BioTherapeutics announces clinical collaboration
Colon Cancer - Regular aerobic exercise significantly reduces markers of colon-cancer risk in men
Diabetes Mellitus - MannKind completes enrollment in phase III study of Technosphere Insulin
Diabetes Therapy - Autologous serum leads to faster corneal epithelial abrasion closure in diabetics
Diabetes Therapy - Glibenclamide and inhaled human insulin equally effective in improving glycemic control
Diabetes Therapy - Insulin detemir and NPH show linear dose-response relationship among type 2 diabetics
Diabetes Therapy - Takeda's Actos demonstrates improvements in cardiovascular outcomes for patients with diabetes
Diabetic Macular Edema - Trial data show SurModics' intravitreal implant well tolerated in diabetic macular edema
Diabetic Retinopathy - Different diabetic macular edema treatments offer comparable results in early studies
Diet & Nutrition - Low-fat vegan diet improves glycemic control and cardiovascular risk in type 2 diabetes
Drug Development - Patients with solid tumors had manageable toxicity when treated with OSI-7836
Endometriosis - Ardana reports positive phase I results for endometriosis
Endometriosis - Trial results show endometriosis pain reduced with orally active GnRH receptor antagonist
Esophageal Cancer - Esophageal cancer patients responded to nedaplatin, 5-fluorouracil, and radiotherapy
Finance - Anthera Pharmaceuticals secures $36 million venture financing
Finance - Palatin Technologies reports fourth quarter fiscal year end 2006 results
Finance - Spacelabs Healthcare reports revenue up 12.7% to $220.6 million for year ended June 30, 2006
Follicular Thyroid Tumors - Follicular thyroid tumor aneuploidy linked to H-RAS 81 polymorphism
Gastric Cancer - Gastric cancer patients' first-degree relatives did not exhibit unusual ras expression
Gastric Cancer - Gastric cancer should not be treated by left thoracoabdominal approach
Gastroesophageal Reflux Disease - Dynogen initiates Phase 1b trial of DDP733 in gastroesophageal reflux disease
HIV/AIDS Education - Educational video during informed consent of HIV clinical trial ensures comprehension
HIV/AIDS Therapy - Cellulose sulfate gel appears safe and well tolerated as contraceptive/antimicrobial agent
HIV/AIDS Vaccine - AlphaVax reports AIDS vaccine induced antibody response to HIV gag antigen in 100% of recipients
Head & Neck Cancer - Head and neck cancer-associated mucositis reduced by intravenous L-alanyl-L-glutamine
Heart Attack - Study suggests heart attack patients do better with sirolimus-eluting than bare metal stents
Heart Failure - Cytokinetics presents Phase I clinical trial data for cardiac myosin activator CK-1827452
Heart Failure - New Alteon management focuses on developing alagebrium in diastolic heart failure
Hepatitis B Vaccine - Hepatitis B virus coadministered hexavalent vaccine evaluated
Hepatitis B Virus - Hepatitis B virus-related cirrhosis relationship to Child-Pugh scores studied
Hepatitis C Virus - Hepatitis C virus core protein induces interleukin production in lymphoma
Hypertension - Medicines Company completes clevidipine safety trials, initiates severe hypertension trial
Hypogonadism - Ardana reports positive phase II results for testosterone cream for hypogonadal men
Influenza Vaccine - Iomai gets go-ahead for study comparing flu vaccine patch to traditional vaccine
Insomnia - Somaxon reports positive update on preclinical, clinical studies of doxepin HC1 for insomnia
Leukemia - VioQuest doses first patient in trial of triciribine-phosphate as leukemia treatment
Lipid Research - High-density lipoprotein cholesterol in cardiovascular disease prevention, treatment is reviewed
Lung Cancer - Lung cancer progression may be revealed by circulating endocan levels
Lung Cancer - Lung cancer risk may rise in smokers with gene variants
Lung Cancer - Lung cancer risk perception among current and former smokers compared
Macular Degeneration - Acuity reports positive phase II results for Bevasiranib in wet age-related macular degeneration
Market Analysis - Twenty-eight percent of pharma firms lack investigator-initiated trial tracking systems
Melanoma - AmpliMed reports positive interim phase I/II results for Amplimexon for melanoma
Melanoma - Thrombocytopenia may be a positive predictive factor for response to melanoma therapy
Melanoma Vaccine - Efficacy of peptide vaccines for metastatic melanoma is examined
Mergers & Acquisitions - Infinity announces completion of merger with Discovery Partners International
Microbial Colonization - Impact of gut microbiota composition on cytokine profile development evaluated in children
Mucinous Cancer - Selected mucinous cancer patients benefit from cytoreductive surgery and intraperitoneal chemotherapy
Multiple Sclerosis - BioMS Medical expands pivotal multiple sclerosis trial into Spain and Germany
Nasopharyngeal Carcinoma - Nasopharyngeal carcinoma survival improved after adding induction chemotherapy to radiotherapy
Nonsmall Cell Lung Cancer - BMI and cytokines levels did not predict nonsmall cell lung cancer survival
Obesity Research - Activation of dopamine D2 receptors lowers circulating leptin levels in obese women
Obesity Therapy - Arena Pharmaceuticals initiates lorcaserin phase III obesity clinical trial
Ophthalmology - Novadaq updates OPTTX clinical results
Ophthalmology - Oxigene to focus on CA4P for age-related macular degeneration
Osteoporosis - One-year soy isoflavone supplementation prevents early postmenopausal bone loss
Pain Management - Javelin's phase IIB study finds low doses of Dyloject rapidly relieve postop pain
Pancreatic-Head Adenocarcinoma - Pancreatic-head adenocarcinoma treated by pancreaticoduodenectomy with mesentericoportal vein resection
Patents - PharmaGap announces patent filings for lead drug; focus on clinical trials of PhGalpha1
Patents - Vical extends patent coverage of Vaxfectin adjuvant to include conventional vaccines
Personnel - CellPoint adds F. David Rollo, MD, PhD, as president
Pharmaceutical Research - Pharmacopeia earns milestone payment from Schering-Plough as product enters clinical trial
Pharmacology - Nebivolol is considered in review of clinical and pharmacological characteristics
Phenylketonuria - BioMarin, Serono report data on Phenoptin
Polycystic Ovary Syndrome - Polycystic ovary syndrome is associated with reduced cardiopulmonary function
Psoriasis - Can-Fite to develop CF101 for psoriasis and other indications, prepares for Phase II clinical trial
Pulmonary Arterial Hypertension - Myogen's ambrisentan data presented at World Congress of Cardiology 2006
Pulmonary Tuberculosis Treatment - Moxifloxacin shows increased activity after 4 weeks of pulmonary tuberculosis treatment
Rectal Cancer - Rectal cancer patients had positive postoperative reappraisal of abdominoperineal resection
Rheumatoid Arthritis - No detectable benefit of ABN912 seen in patients with rheumatoid arthritis in trial
Sexual & Reproductive Health - Alvimopan improves gastrointestinal recovery after total hysterectomy
Sickle Cell Anemia - Icagen reports data monitoring committee meeting results in phase III trial of ICA-17043
Stomach Cancer - Stomach cancer risk potentially linked to processed meat consumption
Strep Throat - Advancis on track to file new drug application for amoxicillin Pulsys for strep throat
Stroke - Research shows clot-buster Desmoteplase may be useful in hemorrhagic stroke
Stroke Therapy - Results of safety study of albumin therapy for ischemic stroke are reported
Surgical Technology - New type of jejunal interposition method after gastrectomy for gastric cancer described
Tracheal Cancer - Adenoid cystic carcinoma of the trachea management techniques discussed
Type 2 Diabetes - Phase III data shows significant glucose-lowering efficacy of Januvia with metformin
Type 2 Diabetes - Study shows Exenatide as effective as biphasic insulin in controlling blood sugar levels
Type 2 Diabetes - Women with type 2 diabetes have increased risk of macrovascular disease compared to men
Urology - Data show solifenacin 5 mg is superior to tolterodine ER 4 mg in treating OAB incontinence
Vaccine Development - Pentavalent bacterial-viral vaccine can provide protection against 5 major childhood pathogens
Vitreoretinal Research - ThromboGenics completes enrollment for phase 2 trial to assess microplasmins in vitrectomy
Arthritis - Research from Germany, Austria and the United States in arthritis provides new insights
Brain Cancer - Researchers from the United States and Brazil provide details of new studies and findings in the area of brain cancer
Breast Cancer - Recent studies from Italy, the United Kingdom and the United States add new data to breast cancer research
Cancer Treatment - Recent studies from the United States and Germany add new data to cancer treatment research
Cancer Treatment - Researchers' findings from Japan and Germany advance cancer treatment research
Cardiology - Researchers from the United States, Germany and Japan describe findings in cardiology studies
Cardiology - Studies from the United States and Germany describe new findings in cardiology research
Diabetes - Findings from South Korea, India and United States describe new data in diabetes research
Diabetes - Recent findings in diabetes described by researchers from Taiwan, the United States and Finland
Diabetes - Studies from Taiwan, Belgium and the United States describe new findings in diabetes research
Heart Attack - Research from Australia, Scotland and Denmark add new data to heart attack body of knowledge
Heart Attack - Researchers' work from Germany, France and the People's Republic of China adds to heart attack body of knowledge
Hepatitis B Virus - New findings from Canada and Turkey in the area of hepatitis B virus detailed
Hepatitis B Virus - Researchers from South Korea, Taiwan and Italy report recent findings in hepatitis B virus
Hepatitis C Virus - New findings in hepatitis C virus described from Italy and the United States
Hepatitis C Virus - Reports from France, Switzerland and Canada add new data to hepatitis C virus research
Leukemia - Studies from Greece, the United States and France describe new findings in leukemia research
Lung Cancer - New findings from Italy, the United States and Japan in the area of lung cancer detailed
Lymphoma - New data from Israel, the People's Republic of China and Taiwan lluminates research in lymphoma
Lymphoma - Recent studies from the United States, Israel and Italy add new data to lymphoma research
Lymphoma - Researchers from France, Japan and Australia describe findings in lymphoma studies
Oncology - Researchers from Denmark and the United States report recent findings in oncology
Osteoporosis - New findings from the United Kingdom and Japan in the area of osteoporosis detailed
Pain - New findings in pain described from the United States
Prostate Cancer - New findings from Italy, the United States and the South Korea in the area of prostate cancer described
Prostate Cancer - Recent findings in prostate cancer described by researchers from the United States
Prostate Cancer - Researchers' work from Sweden and Canada adds to prostate cancer body of knowledge
Transplants - New data from Spain, Austria and the United States lluminates research in transplants
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