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Clinical Trials Week

Susan Hasty, Publisher

Table of Contents . . . October 16th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Clinical Trials Week | Other Publications

Cardiology - Women with atrial fibrillation were more prone to anticoagulant-related bleeding than men

Clinical Trials - Recurrence prevention in lone paroxysmal atrial fibrillation is better with amiodarone combinations

Diabetes Therapy - Rosiglitazone is effective and well tolerated in therapeutic regimens in type 2 diabetes

Lymphoma - Lymphoma patient survival was better with high-dose methylprednisolone versus whole-brain radiotherapy

Allergy & Immunology - Cytos Biotechnology's CYT003-QbG10 achieves efficacy in phase IIa pilot study

Alzheimer Disease - Medivation reports phase 2 trial of Alzheimer drug meets all five efficacy endpoints

Alzheimer Disease - Roskamp Institute announces launch of clinical study on Alzheimer treatment

Angiology - Inhibition of thrombin generation is reversed by a recombinant factor

Angiology - Recurrent venous thromboembolism is associated with polymorphism homozygosity

Antibacterial Agents - Chlorhexidine-impregnated dressing reduces vascular and epidural catheter colonization

Antifungal Therapy - Published study finds Candida albicans rapid diagnostic text saves on antifungal therapy costs

Asthma - Study shows MP3 players useful in getting asthma management information to adolescents

Atherosclerosis - Coronary disease markers are unaffected by modest dosing of renin-angiotensin system inhibition

Avian Influenza Vaccine - sanofi pasteur generates first clinical trial lot of cell-based H7N1 vaccine for bird flu

Basal Cell Cancer - Basal cell carcinoma of the nasolabial fold required more complex surgery

Benign Prostatic Hyperplasia - Nymox announces positive results from benign prostatic hyperplasia trial

Blood Disorders - New once-daily oral iron chelator treats iron overload

Bone Disease - Amgen presents data on denosumab and sclerostin

Breast Cancer - Breast cancer patients may benefit from individual psychosocial support

Breast Cancer - Breast cancer patients with non-negative margins may be treated with radiotherapy

Breast Cancer - Breast cancer prognosis determined by stage at diagnosis

Breast Cancer - New-onset breast discomfort may be related to increased mammographic density

Business & Finance - Palatin Technologies reports fiscal year end 2006 results

Business Update - Alquest launches medical device-focused clinical trial service in India

Business Update - Opexa begins Phase IIb multiple sclerosis study; reports positive Phase I/II data

Business Update - Poniard Pharmaceuticals expands picoplatin agreement

Business Update - Siemens develops scalable method to transfer data from medical record to data capture system

Cancer Incidence - Increased cancer incidence not associated with fluvastatin treatment

Cancer Research - Researchers report Peregrine's phospholipid-targeted antibodies reduce tumor growth in animals

Cancer Therapy - Hana provides Talvesta (talotrexin) for Injection update

Cancer Therapy - Oral squamous cell carcinoma patient response to intra-arterial chemotherapy reduced by granisetron

Cardiology - Cardiac resynchronization therapy for heart failure reduces mortality

Cardiology - Myocardial infarction genetic risk assessed

Cardiology - Pediatric heart failure is beneficially treated using nesiritide

Cardiovascular Disease - Circadian rhythms are important in drug response in hypertension and coronary heart disease

Cardiovascular Disease - Evidence-based use of levosimendan is reviewed in different clinical settings

Celiac Disease - Alba initiates phase II trial for Zonulin antagonist AT-1001 for autoimmune disorder

Cerebellar Ataxia - Cerebellar ataxias may be differentiated by cerebrospinal fluid analysis

Cervical Cancer - Cervical cancer oxygen tension inversely correlates with circulating endothelial progenitor cells

Chronic Idiopathic Constipation - Sucampo's Amitiza effective in treating constipation in people age 65 and older

Clinical Trials - Acorda announces positive Phase III Fampridine-SR study in people with multiple sclerosis

Clinical Trials - Acrux to start U.S. trial of its testosterone lotion for men

Clinical Trials - Angiographic isthmus evaluation may predict efficacy of RF catheters and risk of crossover

Clinical Trials - Cardioprotective effects of sevoflurane were not supported

Collaborations - ACRS and WebbWrites announce strategic alliance

Critical Care Medicine - Severely injured patients examined for toll-like receptor expression

Crohn Disease - Avidia initiates trial of inhibitor of interleukin-6 for Crohn disease

Dental Research - Dental implants with a natural taper design are assessed in clinical practice

Dermatology - NUCRYST Pharmaceuticals announces preliminary results of Phase II dermatology study

Diabetes & Erectile Function - In men with type 1 diabetes, vardenafil significantly improves erectile function

Diabetes Prevention - GlaxoSmithKline's Avandia reduced risk of progression from pre-diabetes to type 2 diabetes

Diabetic Neuropathy - Sangamo presents positive results on DNA-binding protein therapy in diabetic neuropathy

Drug Development - Acceleron Pharma presents positive ACE-011 preclinical data

Drug Development - CepTor executes Letter of Intent with Ferring for late-stage product targeted for Phase 2B trials

Drug Development - Critical Therapeutics announces results of CTI-01 Phase II trial

Drug Development - Prometic expands sites for PBI-1402 trials for anemia

Finance - Array BioPharma receives phase II milestone payment from AstraZeneca

Gastric Cancer - Gastric intestinal metaplasia's link to COX-2 inhibitors requires further investigation

Gastroenterology - Progenics, Wyeth start Phase III clinical program of intravenous methylnaltrexone for post-op ileus

Gaucher Disease - Positive results in studies on mechanism of Amicus' treatment for Gaucher disease published

Genetics & Genomics - A novel trinucleotide repeat expansion identified

HIV/AIDS HAART - Simplified maintenance therapy with atazanavir-ritonavir maintains virologic suppression

Hemodialysis - Positive preclinical data released on Vascular Wrap

Hepatitis A Virus - Hepatitis A virus-Helicobacter pylori association documented

Hepatitis B Virus - Chronic hepatitis B core promoter mutations associated with viral breakthrough

Hepatitis C Therapy - Peregrine's antiphospholipid platform broadened by newly validated anticancer target

Hepatitis C Virus - Chronic hepatitis C risk of hepatocellular carcinoma is related to a promoter

Hypertension - BioMarin completes enrollment of phase II study of 6R-BH4

Imaging - Nasopharyngeal carcinoma detected by F-18-fluoro-2-deoxy-D-glucose positron emission tomography

Intraocular Pressure - pSivida begins phase II clinical study of Mifepristone ophthalmic product

Kidney Disease - Implantable cardioverter defibrillator recipients with renal insufficiency have high mortality

Liver Cancer - BioAlliance reports final results of its doxorubicin Transdrug phase I/II trial for liver cancer

Lung Cancer - Gene mutation in lung cancer patients outpaces copy number for predicting gefitinib sensitivity

Lung Cancer - Lung cancer patients selected for resection by Xe-133-radiospirometry

Lung Cancer - OSI Pharmaceuticals launches study of Tarceva as adjuvant treatment for non-small cell lung cancer

Lymphoma - Pharmion initiates Phase II clinical trial in B-cell lymphoma

Market Analysis - Report examines the issues and concerns about translational medicine, how they can be addressed

Medical Devices - NuVasive treats first patient with NeoDisc cervical disc replacement

Melanoma - Dr. Steven O'Day announces positive results in multicenter trial of new agent against melanoma

Melanoma - SciClone, Sigma-Tau present encouraging interim data on malignant melanoma response trial

Mental Health - Survey to compare women with/without borderline personality disorder was evaluated

Mental Health - Traumatic brain injury patients may benefit from creatine administration

Mergers & Acquisitions - INC Research acquires Pharmaceutical Resource Corp.

Myeloid Leukemia - Initial patients treated in multinational phase II/III study of ChemGenex's Ceflatonin

Neuropathic Pain - Pfizer's Lyrica approved in Europe for difficult-to-treat nerve pain

Non-Small Cell Lung Cancer - Talabostat non-small cell lung cancer trial presented at gene therapy of cancer conference

Nonmelanoma Skin Cancer - Nonmelanoma skin cancer prophylaxis accomplished via facial resurfacing

Obesity Therapy - OREXIGEN reports positive 24-week results for Contrave phase III obesity treatment study

Obstetrics - Pregnant women respond favorably to uterine artery ligation treatment for uterine fibroids

Ophthalmology - An egg a day helps promote eye health

Orthopedics - Aastrom Biosciences reports interim data from phase I/II trial of tissue repair cells

Pancreatic Cancer - An in vivo platform is needed for optimal translational drug development in pancreatic cancer

Paroxysmal Nocturnal Hemoglobinuria - Alexion submits biologics license application for Soliris to treat blood disorder

Paroxysmal Nocturnal Hemoglobinuria - Monoclonal antibody drug eculizumab improves PHN hemolytic anemia symptoms, study shows

Patents - Ortec obtains second U.S. patent allowance on haptide cell attachment technology

Pediatric Cancer - Pediatric cancer patients commonly administered psychotropic medication

Pediatrics Otorhinolaryngology - Adenotonsillectomy effect on serum immunoglobulin levels in children is assessed

Personnel - Immune Response Corporation adds James L. Foght, PhD, to board of directors

Prostate Cancer - Antisoma presents positive data from AS1404 phase II trial in prostate cancer

Prostate Cancer - Prostate cancer detected by DNA integrity assay

Prostate Cancer - Prostate cancer patients responded to higher dose of docetaxel

Prostate Cancer - Prostate cancer prevention strategies should target individual's specific risk factors

Sexual & Reproductive Health - Ovarian size may be related to risk of tumor development in postmenopausal women

Sexual & Reproductive Health - Position on use of hormone therapy in Latin America women has been released by expert panel

Statins - Statin therapy pleiotropic effects extend their use to intensive care units

Statins - Statins for treating inflammation in acute coronary syndromes are focus of review

Surgical Technology - Gastric cancer treated by high segmental gastrectomy

Surgical Technology - The ProDisc-L artificial disc proved superior to spinal fusion

Type 2 Diabetes - NovoMix 30 insulin is alternative to basal-bolus therapy for Type 2 diabetes

Vaccine Efficacy - Probiotics improve vaccine antibody responses to Hib vaccine in allergy-prone infants

Virology - Researchers are investigating whether reovirus can be used to treat malignant glioma

Asthma - Recent findings in asthma described by researchers from South Korea, Japan and Italy

Brain Cancer - New findings from the United States and Spain in the area of brain cancer detailed

Brain Cancer - Recent findings in brain cancer described by researchers from the United States, Austria and South Korea

Breast Cancer - Findings from the United Kingdom in breast cancer provide new insights

Breast Cancer - New findings in breast cancer described from U, the United States and Brazil

Breast Cancer - Research from Italy and Netherlands add new data to breast cancer body of knowledge

Breast Cancer - Research from the United States and Taiwan in breast cancer provides new insights

Breast Cancer - Researchers' work from France, the United Kingdom and the United States adds to breast cancer body of knowledge

Cancer Treatment - Researchers from Australia and the United States provide details of new studies and findings in the area of cancer treatment

Cardiology - New findings from the United States, Germany and Canada in the area of cardiology described

Cervical Cancer - Studies from the United States, Italy and United Kingdom advance knowledge in cervical cancer research

Clinical Trials - Studies from the United States and Italy describe new findings in clinical trials research

Colorectal Cancer - Researchers from Scotland, Italy and the South Korea publish new studies and findings in the area of colorectal cancer

Depression - Recent findings from the United States and Italy illuminate research in depression

Depression - Recent studies from the United States and Argentina add new data to depression research

Diabetes - New findings from Japan, Austria and the United States in the area of diabetes detailed

Diabetes - Reports from Germany and the United States advance knowledge in diabetes research

Diabetes - Researchers from Sweden, the United Kingdom and Russia provide details of new studies and findings in the area of diabetes

Diabetes - Researchers from Taiwan, the United States and Finland provide details of new studies and findings in the area of diabetes

Diabetes - Researchers from the United States and Canada publish new studies and findings in the area of diabetes

Gastric Cancer - Reports from Japan add new data to gastric cancer research

HIV/AIDS - Studies from the United States and Spain describe new findings in HIV/AIDS research

Heart Disease - New research from the United States, France and Scotland in the area of heart disease detailed

Hepatitis C Virus - Findings from Brazil, the United States and Spain advance knowledge in hepatitis C virus research

Hepatitis C Virus - New research from Greece, the United States and India in the area of hepatitis C virus detailed

Hepatitis C Virus - Reports from Germany, Japan and Sweden add new data to hepatitis C virus research

Hepatitis C Virus - Reports from the United States and Denmark advance knowledge in hepatitis C virus research

Hepatitis C Virus - Research from the United States and Switzerland in hepatitis C virus provides new insights

Influenza - Reports from the United States and United Kingdom advance knowledge in influenza research

Leukemia - Reports from the United States describe recent advances in leukemia research

Lung Cancer - Findings from Japan and Taiwan describe new data in lung cancer research

Lung Cancer - Findings from the United States advance knowledge in lung cancer research

Lung Cancer - New data from the United States and Austria lluminates research in lung cancer

Lung Cancer - Studies from Italy, France and the United States advance knowledge in lung cancer research

Lymphoma - Recent findings in lymphoma described by researchers from Israel, Taiwan and the United States

Lymphoma - Researchers' findings from the Czech Republic and United States advance lymphoma research

Malaria - Reports from the United States and United Kingdom add new data to malaria research

Medical Devices - Data from the United States and Germany advance knowledge in medical devices research

Melanoma - Researchers from the United States, Australia and Germany detail new studies and findings in the area of melanoma

Osteoporosis - New research from the United States in the area of osteoporosis detailed

Rectal Cancer - New findings from the United States, United Kingdom and Germany in the area of rectal cancer detailed

Rotavirus - Researchers' work from Finland, the United States and Colombia adds to rotavirus body of knowledge

Stroke - Research from Mexico and the United States add new data to stroke body of knowledge

Surgery - Research from the United Kingdom and Hungary in surgery provides new insights

Transplants - Researchers from the United States, Brazil and Germany report details of new studies and findings in the area of transplants

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