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Seattle Genetics initiates phase 1 trial of SGN-35 in Hodgkin, other hematologic malignancies

Published in Clinical Trials Week, December 18th, 2006

Seattle Genetics, Inc. (SGEN) announced that it has initiated a phase I clinical trial of SGN-35 for patients with Hodgkin disease and other CD30-positive hematologic malignancies.

SGN-35 is an antibody-drug conjugate (ADC) that utilizes Seattle Genetics' proprietary technology to empower antibodies by linking them to potent cell-killing drugs.

Clay B. Siegall, PhD, president and chief executive officer of Seattle Genetics, said, "Many antibodies lack sufficient potency on their own to have a therapeutic benefit. ADCs exploit an antibody's ability to target tumor cells to deliver a highly potent drug payload, sparing nontargeted cells many of the...

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