Research findings from University of Maryland, Greenebaum Cancer Center update understanding of solid cancer therapy

Scientists discuss in "Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors" new findings in solid cancer. "Based on preclinical data showing synergy between 7-hydroxystaurosporine (UCN-01) and platinum agents, a phase I trial of carboplatin with UCN-01 administered as a 3 h infusion in patients with advanced solid tumors was done. The primary goals of this trial were to evaluate the tolerability of this combination and the pharmacokinetics of UCN-01 when administered over 3 h and to compare the tolerability and pharmacokinetics with previously described schedules. Patients with advanced solid tumors, good performance status, normal organ...

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