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Clinical Trials Week

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Combination Therapy



New combination therapy research has been reported by scientists at University of Texas



August 27th, 2007

According to recent research from the United States, "The use of multiple drugs in a single clinical trial or as a therapeutic strategy has become common, particularly in the treatment of cancer. Because traditional trials are designed to evaluate one agent at a time, the evaluation of therapies in combination requires specialized trial designs."

"In place of the traditional separate phase I and 11 trials, we propose using a parallel phase I/II clinical trial to evaluate simultaneously the safety and efficacy of combination dose levels, and select the optimal combination dose. The trial is started with an initial period of dose escalation, then patients are randomly...


Source: Clinical Trials Week (2007-08-27)

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