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Enzyme Research

Reports from Hokkaido University highlight recent research in enzyme research

Published in Clinical Trials Week, December 3rd, 2007

"Dabigatran etexilate ( BIBR-1048, Rendix), an orally active prodrug of the thrombin inhibitor dabigatran ( BIBR-953ZW), is being developed by Boehringer Ingelheim Corp as a potential antithrombotic agent," scientists writing in the journal Current Opinion in Investigational Drugs report.

"By March 2003, the compound was in phase IIb/ III trials for the prevention of deep vein thrombosis. By November 2005, a phase III trial had been initiated for the prevention of stroke and embolism due to atrial fibrillation and in May 2006 phase III trials for the prevention of secondary venous thromboembolism began," wrote M. Ieko and colleagues, Hokkaido University.

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