Chronic Myeloid Leukemia

Recent findings in chronic myeloid leukemia described by R. Capdeville and colleagues

Published in Clinical Trials Week, August 11th, 2008

"Imatinib is a selective inhibitor of the BCR/ABL tyrosine kinase. The remarkable initial results of the first phase I clinical trial published in 1999 prompted the rapid initiation of large phase II trials," scientists in Basel, Switzerland report.

"They also generated intense media coverage and significant interest from patients and clinicians and demand for access to imatinib before marketing approval. In response, a worldwide expanded access program (EAP) for imatinib was implemented in May 2000. In total, 7380 patients with chronic myeloid leukemia (CML) and acute lymphoblastic leukemia failing prior therapies were enrolled in 106 centers in 34 countries. Time to...

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Source: Clinical Trials Week (2008-08-11)

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