HIV/AIDS Vaccines

Research reports from Fred Hutchinson Cancer Research Center provide new insights into HIV/AIDS vaccines

Published in Clinical Trials Week, October 13th, 2008

Research findings, 'On modeling the effects of T-cell vaccines on HIV acquisition and disease,' are discussed in a new report. According to recent research from the United States, "A 'T-cell vaccine' aims at generating cytotoxic T-lymphocytes (CTLs; the so-called 'killer' T-cells) rather than antibodies (as for traditional vaccines). The first (phase IIb) trials of this concept against HIV/AIDS began in 2004."

"What can mechanistic modeling contribute to understanding the biological action of this class of vaccines, if any' Models are appropriate in any discussion of three potential vaccine effects: on acquisition of infection; on state of disease ('viral load', VL)...

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Source: Clinical Trials Week (2008-10-13)

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