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Clinical Trials Week


Susan Hasty, Publisher
Table of Contents . . . June 15th, 2009
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Clinical Trials Week | Other Publications

Abraxis BioScience, Inc. - New Study Results Published Compare ABRAXANE® to Taxotere®

Cystinosis - Raptor Pharmaceuticals Doses First Patient in Phase 2b Clinical Trial of DR Cysteamine for Cystinosis

Enzon Pharmaceuticals, Inc. - Enzon Presents Clinical Data from HIF-1 Alpha Antagonist Study at ASCO

Esophageal Cancer - Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

Exelixis, Inc. - Exelixis and BMS Report Phase 2 Data to Be Presented at ASCO for XL184 in Patients with Previously Treated Glioblastoma Multiforme

Halozyme Therapeutics, Inc. - Phase 1 Study for Halozyme’s Insulin-PH20 Published, Highlights Findings for Faster Acting Insulin Formulations

Hepatitis C Virus - Anadys Pharmaceuticals, Inc. Announces Strategic Restructuring to Focus Operations on Continuing the Advancement of ANA598

Leukemia - Access Pharmaceuticals Announces Publication of Thiarabine Combination Data

Liver Disease - Valeant Pharmaceuticals Reports Encouraging Final Results With Taribavirin Phase IIb Study

Prostate Cancer - PROSTVAC(TM) Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer

Schizophrenia - Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in the Journal of Clinical Psychiatry

Acute Myeloid Leukemia - Reports from Y. Kobayashi et al highlight recent research in acute myeloid leukemia

Emphysema - Research reports from Temple University provide new insights into emphysema

Epilepsy - Findings from S.A. Cross and co-researchers advance knowledge in epilepsy

Graft-Versus-Host Disease - Reports outline graft-versus-host disease research from C. Martinez and colleagues

Human Papillomavirus Vaccines - Findings in human papillomavirus vaccines reported from E. Barthell and co-researchers

Pharmacodynamics - Reports summarize pharmacodynamics research from E. Vets and co-authors

Prostate Cancer - New findings in prostate cancer described by J. Horti and co-researchers

Angiogenesis - Scientists at Nanjing Medical University, Department of Cardiovascular Medicine discuss research in angiogenesis

Colon Cancer Therapy - Study results from Cancer Center update understanding of colon cancer therapy

Abraxis BioScience, Inc. - Study Explores Potential Benefit of Nab®-Paclitaxel in Combination with Bevacizumab for the First-Line Treatment of Metastatic Breast Cancer

Alder Biopharmaceuticals, Inc. - Alder Biopharmaceuticals Presents Results From Phase 1 Trial of ALD518 in Advanced Cancer at American Society of Clinical Oncology Annual Meeting

Amyotrophic Lateral Sclerosis - AIMSPRO is Awarded TGA Orphan Status for the Treatment of Amyotrophic Lateral Sclerosis

Asymchem Laboratories, Inc. - Asymchem Announces sFDA Certification for Drug Product Manufacturing

Bavarian Nordic A/S - PROSTVAC Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer

BioLineRx Ltd. - BioLineRx Announces Positive Preliminary Results From the Phase I/II Trial of BL-1040, the First Injectable Device Addressing Pathological Cardiac Remodeling

Brain Cancer - Neurobiological Technologies' Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program

Breast Cancer - CuraGen Updates CR011-vcMMAE Data at ASCO

Breast Cancer - Peregrine Pharmaceuticals Presents Promising Data From Its Phase II Bavituximab Breast Cancer Trial at 2009 ASCO Annual Meeting

Can-Fite BioPharma - Can-Fite-Completed Patient Enrollment for the Phase II Trial in Psoriasis With CF101

Cancer - Bayer Announces New Data on Novel Anti-cancer Compound BAY 73-4506

Cancer - Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

Celldex Therapeutics, Inc. - Celldex Therapeutics Announces CDX-1307 Clinical Data at 45th Annual ASCO Meeting

Celldex Therapeutics, Inc. - Pfizer and Celldex Therapeutics Present Update on CDX-110 PF-04948568 Phase 2 Brain Cancer Studies at 45th Annual ASCO Meeting

ChemGenex Pharmaceuticals Limited - Pivotal Study Results: ChemGenex’s Omacetaxine May Provide the First Viable Drug Treatment Option for Patients With a Highly Resistant Form of CML

Chronic Lymphocytic Leukemia - Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

Clinical Trial Research - OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial

Clinical Trial Research - Rigel's R788 Evaluated in Phase 2 Trial in Multiple Cancers

Colon Cancer - AEterna Zentaris Partner Keryx Reports Positive Phase 2 Data for Perifosine (KRX-0401) in Colon and Kidney Cancer at ASCO Meeting

Colon Cancer - Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Adv

Concert Pharmaceuticals - Concert Pharmaceuticals and GlaxoSmithKline Form Alliance to Develop Novel Deuterium Modified Drugs

Crohn Disease - New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease

Crohn Disease - PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference

Depomed, Inc. - Depomed Completes Enrollment of Phase 3 Clinical Program of DM-1796 in Post-Herpetic Neuralgia

Drug Development - Cordex Receives Special Protocol Assessment Approval from FDA for ATPace(TM)

Elan Corporation, plc and Biogen Idec - Subset Data from Two Randomized Phase 3 Trials Show TYSABRI® Significantly Improves Health-Related Quality of Life for Crohn’s Disease Patients with Prior Exposure or Inadequate Response to Anti-TNFa Therapy

Enzo Biochem, Inc. - Data from Enzo Therapeutics’ Phase II Study of Crohn’s Disease Presented at Prestigious Gastroenterology Conference

Exelixis, Inc. - Exelixis Reports Encouraging Phase 1 Data To Be Presented at ASCO for XL765, a Dual Inhibitor of PI3K and mTOR

Gene Therapy - PARI Pharma Reports Successful Phase Ib Clinical Results for Inhaled Liposomal Cyclosporine a and Gains FDA Orphan Drug Designation for the Prevention and Treatment of Bronchiolitis Obliterans

Genta Incorporated - New Clinical Data for Tesetaxel, a Leading Oral Taxane, Show Anticancer Activity and Acceptable Safety in Ongoing Study

Genzyme Corp. - Genzyme Completes Transaction with Bayer HealthCare

Gloucester Pharmaceuticals - Gloucester Pharmaceuticals Presents Positive Clinical Data for Romidepsin in CTCL and Further Preclinical Evidence of Synergism with Bortezomib at ASCO

GlycoMimetics, Inc. - Dana-Farber Cancer Institute Presents Results of GlycoMimetics’ Lead Drug Candidate in Models of Multiple Myeloma at American Society of Clinical Oncology Annual Meeting

Head and Neck Cancer - Induction Chemotherapy Followed by ChemoRadiotherapy Increased Time-to-Treatment Failure Compared to ChemoRadiotherapy Alone in Patients With Unresectable Locally Advanced Head & Neck Cancer

Heart Failure - Results and Additional Analyses From Study Show That Corthera's Relaxin for Acute Heart Failure is the Strongest Predictor of Improved Longer-Term Outcomes Following Hospital Discharge When Compared to Other Variables

Horizon Therapeutics, Inc. - Horizon Therapeutics' HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain

Kureczka/Martin Associates - ChemGenex's omacetaxine may provide first viable treatment option for highly resistant form of CML

Merck & Co., Inc. and AstraZeneca - AstraZeneca and Merck & Co., Inc. Form Pioneering Collaboration to Investigate Novel Combination Anticancer Regimen

Merck KGaA - Merck KGaA: Follow-Up From Stimuvax Study Provides Long-Term Safety Data In Advanced Lung Cancer Patients Receiving Treatment for Up To 8.2 Years

Merck KGaA - Merck KGaA: Study Shows Cilengitide Increased Overall Survival in Patients With Glioblastoma

Mersana Therapeutics, Inc. - Mersana Reports Preliminary Phase 1 Results of XMT-1001 in Patients with Advanced Solid Tumors

Millennium: The Takeda Oncology Company Millennium: The Takeda Oncology Company - The Addition of VELCADE® Bortezomib for Injection to New and Standard Combinations Delivers Promising Results in Patients with Non-Hodgkin’s Lymphoma

Myeloma - Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

Neoprobe Corporation - Neoprobe’s Second Phase 3 Lymphoseek Study Commences

Neuroendocrine Cancer - Delcath Systems Granted Third Orphan Drug Designation

New England Research Institutes, Inc. - NERI and ProMedica CRC Form Strategic Alliance to Support Phase I-IV Clinical Research Studies

Non-Small Cell Lung Cancer - Bayer and Onyx Initiate Phase 3 Trial of Nexavar in Non-Small Cell Lung Cancer

Ovarian Cancer - Telik Presents Results at ASCO From ASSIST-5 Trial of TELCYTA in Platinum Refractory and Resistant Ovarian Cancer

Pfizer - New Pfizer Data Helps to Identify Kidney Cancer Patients Who May Be Most Likely to Benefit from Treatment

Pfizer Inc - Pfizer Data Identify Certain Lung Cancer Patients Who May Benefit from Treatment with Figitumumab

Pfizer Inc - Pfizer Discontinues SUN 1094 Trial of Sunitinib plus Paclitaxel in Advanced Breast Cancer

Pfizer Inc - Pfizer Presents Data With Novel Investigational Agents In Select Patient Groups With Non-Small Cell Lung Cancer

Pharmaceuticals - Optimer Pharmaceuticals Announces Lower Recurrence Rates for Fidaxomicin Versus Vancocin(R) in Subgroup Analyses from Its Phase 3 Study for the Treatment of CDI

Plexxikon Inc. - Plexxikon Announces PLX4032 Phase 1 Data Showing Objective Responses in Metastatic Melanoma Patients

Prostate Cancer - Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO

Prostate Cancer - Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

Salix Pharmaceuticals - Salix’s Once-Daily APRISO Demonstrates Long-Term Safety in Patients for Maintenance of Remission from Ulcerative Colitis

Sarah Cannon Research Institute - Sarah Cannon Research Institute to Present Latest Cancer Research Data at National Clinical Oncology Conference

Sarcoma - Oncolytics Biotech(R) Inc. Collaborators Present Positive Phase II Sarcoma Trial Results at ASCO Annual Meeting

Seattle Genetics, Inc. - Seattle Genetics Reports Data from a Weekly Dosing Phase I Clinical Trial of SGN-35 in Lymphoma

Solid Cancer - LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit

Solid Cancer - Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

Solid Cancer - Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

StemCells, Inc. - StemCells, Inc. to Present Phase I Clinical Trial Results at the 12th International Congress on NCL

Tuberculosis - Data On Investigational Drug TMC207 for Treatment of MDR-Tuberculosis, Published in New England Journal of Medicine

Xencor, Inc. - Xencor Presents Preliminary Phase I Data on XmAb®2513 Antibody for Lymphomas at 2009 American Society of Clinical Oncology Annual Meeting

XenoPort, Inc. - XenoPort Data Presented at Digestive Disease Week Meeting Demonstrates Arbaclofen Placarbil Monotherapy Reduces Heartburn and Regurgitation in GERD Patients Previously Treated with PPIs

ZIOPHARM Oncology, Inc. - ZIOPHARM Presents Positive Darinaparsin Clinical Data at ASCO’s Prestigious Clinical Science Symposium

ZIOPHARM Oncology, Inc. - ZIOPHARM Presents Positive Data from Phase I Study of Palifosfamide in Combination with Doxorubicin at ASCO

ZIOPHARM Oncology, Inc. - ZIOPHARM Presents Positive Indibulin Translational and Dose Scheduling Data at ASCO

ZymoGenetics, Inc. - ZymoGenetics Reports Encouraging Phase 2 Results in Renal Cell Cancer for IL-21 with Nexavar®



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