Alopecia Areata

Studies from University of Texas update current data on alopecia areata

Published in Clinical Trials Week, November 9th, 2009

"Alopecia areata, hair loss caused by perifollicular T-cell infiltrates, is refractory to therapy. Bexarotene, a retinoid X receptor is a selective retinoid, induces T-cell apoptosis," scientists in the United States report.

"We sought to determine the safety, including the dose-limiting toxicities with adverse events, and efficacy, ie, response rate, of bexarotene in alopecia areata. We conducted a phase I/II randomized, half-head trial of 1% bexarotene gel applied twice daily for 6 months. In all, 42 patients (11 male and 31 female) with alopecia totalis (n = 3), alopecia universalis (n = 5), or alopecia areata (n = 34) applied 1% bexarotene gel for 24 weeks. Five of...

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Source: Clinical Trials Week (2009-11-09)

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