Cancer Vaccines
Researchers at University of Washington target cancer vaccines
Published in Clinical Trials Week, November 9th, 2009
"The primary objectives of this phase I/II study were to evaluate the safety and immunogenicity of combination therapy consisting of concurrent trastuzumab and human epidermal growth factor receptor 2 (HER2)/neu-specific vaccination in patients with HER2/neu-overexpressing metastatic breast cancer. Twenty-two patients with stage IV HER2/neu-positive breast cancer receiving trastuzumab therapy were vaccinated with an HER2/neu T-helper peptide-based vaccine," scientists writing in the Journal of Clinical Oncology report.
"Toxicity was graded according to National Cancer Institute criteria, and antigen specific T-cell immunity was assessed by interferon gamma...
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Source: Clinical Trials Week (2009-11-09)
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