Published in Clinical Trials Week, January 25th, 2010
"We conducted a phase I trial of flavopiriclol + FOLFOX (folinic acid, 5FU, and oxaliplatin) for advanced solid tumors. Flavopiridol was administered every 2 weeks with oxaliplatin before 5FU, based on sequence-dependent growth inhibition. Flavopiridol pharmacokinetics and p53 status were evaluated. Forty-eight patients were treated on study. With dose escalation of...
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