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Type 1 Diabetes

Poorer vascularity of pancreatic islet transplants may hamper insulin levels

Published in Diabetes Week, February 17th, 2003

Researchers report low vascular density in transplanted pancreatic islets may have a negative impact on insulin production.

According to recent research from Sweden, "pancreatic islets are avascular immediately after transplantation. Although the islets are rapidly revascularized, it is uncertain whether the revascularization produces an adequate oxygenation of the transplanted islet tissue. We measured pO2 , blood flow, and vascular density in mouse or human islets 1 month after transplantation to nude mice."

"Tissue pO2 was measured with Clark microelectrodes. Blood perfusion was measured with laser-Doppler flow cytometry,...

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