Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men

"The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90-minute intervals for a total of 120 hours, which included 88 hours of sustained sleeplessness, in 10 healthy men," investigators in the United States report.

"The diurnal amplitude of leptin was reduced during total sleep deprivation and returned toward normal during the period of recovery sleep," stated Janet M. Mullington and colleagues at Harvard University and the University of Pennsylvania....

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