Diabetes Pathogenesis

N-ethylmaleimide-sensitive factor required for exocytosis

Published in Diabetes Week, October 20th, 2003

N-ethylmaleimide-sensitive factor is required for exocytosis of insulin-containing secretory granules in pancreatic beta-cells.

"N-Ethylmaleimide-sensitive factor (NSF) has an important role in fusion processes within intracellular compartments and at the plasma membrane, but the exact role of this protein in the exocytotic machinery has not yet been determined," scientists in Sweden report.

"NSF was found to be present in the cytosol of rat pancreatic beta-cells and rat insulinoma INS-1 cells," said J. Vikman and colleagues at Lund University. "Capacitance measurements revealed that exocytosis of primed granules was not affected by the presence of a...

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Source: Diabetes Week (2003-10-20)

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