Animal Models

Glucose homeostasis and insulin signaling characterized in mice strains

Published in Diabetes Week, August 30th, 2004

Scientists have characterized glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice.

"Transgenic mice phenotypes generally depend on the background strains used in their creation. To examine the effects of genetic background on insulin signaling, we analyzed glucose homeostasis in four inbred strains of mice [C57BL/6 (B6), C57BLKS/6 (KLS), DBA/2 (DBA), and 129X1] and quantitated mRNA content of insulin receptor (IR) and its substrates in insulin-responsive tissues. At 2 months, the male B6 mouse is the least glucose-tolerant despite exhibiting similar insulin sensitivity and first-phase insulin secretion as...

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Source: Diabetes Week (2004-08-30)

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