Diabetes Pathogenesis

Lipid-induced insulin secretion impairment reversed with malate analog

Published in Diabetes Week, September 6th, 2004

Scientists have elucidated the biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion.

According to a study from the United States, "Hyperlipidemia appears to play an integral role in loss of glucose-stimulated insulin secretion (GSIS) in type 2 diabetes. This impairment can be simulated in vitro by chronic culture of 832/13 insulinoma cells with high concentrations of free fatty acids, or by study of lipid-laden islets from Zucker diabetic fatty rats. Here we show that impaired GSIS is not a simple result of saturation of lipid storage pathways, as adenovirus-mediated overexpression of a cytosolically localized variant of malonyl-CoA...

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Source: Diabetes Week (2004-09-06)

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