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Cardiovascular Disease
Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in type 1 diabetes
September 27th, 2004
Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in an early stage of type 1 diabetes through activation of JNK. "14-3-3 family members are dimeric, phosphoserine binding proteins that regulate signal transduction, apoptotic, and checkpoint control pathways. Recently, cardiomyocyte apoptosis has been characterized in type 1 diabetes mellitus. In order to study the molecular mechanism underlying diabetes-induced cardiomyocyte apoptosis, we examined the role of 14-3-3 protein and MAPK pathways in transgenic mice with cardiac specific expression of dominant negative 14-3-3eta (DN-14-3-3)," scientists writing in the journal Biochemical and Biophysical Research...
Source: Diabetes Week (2004-09-27)
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