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Diabetes Therapy
Hydrogel sheet macroencapsulation method for bioartificial pancreas developed
September 27th, 2004
Scientists have developed a method for the PVA hydrogel sheet macroencapsulation of the bioartificial pancreas. "We developed a new sheet-type macroencapsulation device entrapping rat islets from 3% polyvinyl alcohol (PVA) dissolved in Euro-Collins solution containing 10% fetal bovine serum and 5% dimethyl sulfoxide (PVA+EC) using a freezing/thawing technique. The same encapsulation technique but with 3% PVA dissolved only in double-distilled water (PVA) and a culture of free islets were served as controls. After 14-day culture in the CMRL-1066 medium, the islet recovery rate, morphological changes, insulin content, and insulin secretion were evaluated in vitro to prove...
Source: Diabetes Week (2004-09-27)
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