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Diabetes Pathogenesis
Nitric oxide plays immunoregulatory role in virus-induced autoimmune diabetes
September 27th, 2004
Nitric oxide plays an immunoregulatory role in Kilham rat virus-induced autoimmune diabetes in DR-BB rats. According to recent research published in the Journal of Immunology, "Macrophages play a critical role in the pathogenesis of Kilham rat virus (KRV)-induced autoimmune diabetes in diabetes-resistant BioBreeding (DR-BB) rats. This investigation was initiated to determine the role of macrophage-derived soluble mediators, particularly NO, in the pathogenesis of KRV-induced diabetes in DR-BB rats. We found that the expression of inducible NO synthase (iNOS), an enzyme responsible for NO production, was significantly increased during the early phase of KRV...
Source: Diabetes Week (2004-09-27)
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