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Endocrinology
Most newly synthesized proinsulin aggregates in non-beta-cell lines
September 27th, 2004
Most newly synthesized proinsulin aggregates in non-beta-cell lines. "Myoblasts transfected with HB10D insulin secrete more hormone than those transfected with wild-type insulin, as published previously, indicating that production of wild-type insulin is not efficient in these cells. The ability of non-beta-cells to produce insulin was examined in several cell lines. In clones of neuroendocrine GH4 C1 cells stably transfected with proinsulin, two-thirds of 35S-proinsulin was degraded within three hours of synthesis, whereas 35S-prolactin was stable," scientists in the United States report. "In transiently...
Source: Diabetes Week (2004-09-27)
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