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Hypertension
Mice with P465L PPAR-gamma exhibit hypertension and abnormal fat distribution
September 27th, 2004
Mice with P465L PPAR-gamma exhibit hypertension and abnormal fat distribution but not insulin resistance. "Peroxisome proliferator-activated receptor gamma (PPAR-gamma), the molecular target of a class of insulin sensitizers, regulates adipocyte differentiation and lipid metabolism. A dominant negative P467L mutation in the ligand-binding domain of PPAR-gamma in humans is associated with severe insulin resistance and hypertension. Homozygous mice with the equivalent P465L mutation die in utero. Heterozygous mice grow normally and have normal total adipose tissue weight. However, they have reduced interscapular brown adipose tissue and intra-abdominal fat mass, and...
Source: Diabetes Week (2004-09-27)
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