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Insulin Resistance
Adenovirus-mediated chronic 'hyper-resistinemia' causes insulin resistance
September 27th, 2004
Adenovirus-mediated chronic 'hyper-resistinemia' leads to in vivo insulin resistance in normal rats. "We investigated the chronic in vivo effect of resistin on insulin sensitivity and glucose metabolism by overexpressing resistin protein in male Wistar rats using intravenous administration of an adenovirus encoding mouse resistin. After 7 days of elevated resistin levels at a supraphysiological concentration, the animals displayed glucose intolerance and hyperinsulinemia during glucose tolerance tests, and insulin tolerance tests demonstrated an impaired glucose-lowering effect of insulin. The glucose clamp studies were performed at submaximal (4 mU/kg/min) and maximal...
Source: Diabetes Week (2004-09-27)
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