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Insulin Resistance
Insulin resistance enhanced in adrenomedullin-deficient mice
September 27th, 2004
Angiotensin II-induced insulin resistance is enhanced in adrenomedullin-deficient. "Insulin resistance and hypertension are common disorders that are closely related. Among several factors, oxidative stress has been reported to be intimately related to these diseases. To elucidate the involvement of oxidative stress in the development of insulin resistance in a hypertensive model, we administered angiotensin II (Ang II), which raises blood pressure and induces reactive oxygen radicals, to adrenomedullin (AM)-knockout heterozygous mice and examined the resulting changes in blood pressure and insulin resistance. Ang II was administered i.p. at a dosage of 640 ng/kg per...
Source: Diabetes Week (2004-09-27)
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