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Metabolism
High glucose levels alter vascular cytokines and capillary structure
September 27th, 2004
High glucose levels alter vascular cytokines and capillary structure. "We studied the effect of a high glucose (HG) environment on the vascular factors that are secreted by mesangial cells, and regulate endothelial growth and mesangial matrix deposition," said scientists in the United States. "To this effect, we measured the vascular factors in the glomeruli of streptozotocin-induced diabetic kidneys and in mesangial cells exposed to a HG concentration. We then transferred the media of mesangial cells previously exposed to high glucose to cultured endothelial cells to study the effects on endothelial growth, matrix formation, and in vitro capillary...
Source: Diabetes Week (2004-09-27)
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