Obesity and Diabetes
Subsarcolemmal mitochondria deficiency found in obesity and type 2 diabetes
Published in Diabetes Week, March 28th, 2005
"The current study addresses a novel hypothesis of subcellular distribution of mitochondrial dysfunction in skeletal muscle in type 2 diabetes. Vastus lateralis muscle was obtained by percutaneous biopsy from 11 volunteers with type 2 diabetes; 12 age-, sex-, and weight-matched obese sedentary nondiabetic volunteers; and 8 lean volunteers. Subsarcolemmal and intermyofibrillar mitochondrial fractions were isolated by differential centrifugation and digestion techniques," investigators in the United States report.
"Overall electron transport chain activity was similar in...
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Source: Diabetes Week (2005-03-28)
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