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Heart Disease Risk Factors

Fatty acid metabolism is enhanced in type 2 diabetic hearts

Published in Diabetes Week, August 1st, 2005

Fatty acid metabolism is enhanced in type 2 diabetic hearts.

"The metabolic phenotype of hearts has been investigated using rodent models of type 2 diabetes which exhibit obesity and insulin resistance: db/db and ob/ob mice, and Zucker fatty and ZDF rats. In general, cardiac fatty acid (FA) utilization is enhanced in type 2 diabetic hearts, with increased rates of FA oxidation (db/db, ob/ob, and ZDF models) and increased FA esterification into cellular triacylglycerols (db/db hearts). Hearts from db/db and ob/ob mice and ZDF rat hearts all have elevated levels of myocardial triacylglycerols, consistent with enhanced FA utilization," scientists in Canada report.

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