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Insulin Resistance

Elevated gamma-glutamyltransferase levels predict reduced insulin sensitivity

Published in Diabetes Week, August 1st, 2005

Elevated serum gamma-glutamyltransferase concentrations predict reduced insulin sensitivity and increased intrahepatic lipids.

According to recent research from Germany, "Elevated serum gamma-glutamyltransferase (GGT) concentrations have been related to features of the metabolic syndrome as well as increased risk of cardiovascular and liver disease. More recently, elevated GGT levels were shown to predict development of type 2 diabetes in a longitudinal study from Korea. The aim of the present study was to test the hypothesis that serum GGT is associated with glucose tolerance, insulin sensitivity, and beta-cell function in a healthy, non-diabetic Caucasian population...

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