Physiology
RNA interference-based screen identifies MAP4K4/NIK as a negative regulator
Published in Diabetes Week, April 10th, 2006
"The insulin-regulated glucose transporter GLUT4 is a key modulator of whole body glucose homeostasis, and its selective loss in adipose tissue or skeletal muscle causes insulin resistance and diabetes.
"Here we report an RNA interference-based screen of protein kinases expressed in adipocytes and identify four negative regulators of insulin-responsive glucose transport: the protein kinases PCTAIRE-1 (PCTK1), PFTAIRE-1 (PFTK1),...
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Source: Diabetes Week (2006-04-10)
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