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Cardiology

Obesity-related heart disease may be linked to plasma endothelial cell-specific molecule-1

Published in Diabetes Week, April 10th, 2006

Obesity-related heart disease may be linked to circulating plasma endothelial cell specific molecule-1.

"Adipocytes produce the endothelial-cell specific molecule-1 (ESM-1), which inhibits leukocyte adhesion and migration through the endothelium. This study investigates ESM-1 expression and regulation in human adipose tissue," scientists in Germany explained.

J. Janke and colleagues of Franz Volhard Klinic in Berlin described their study, "Subcutaneous abdominal adipose tissue was obtained from seventy postmenopausal women. Fourteen women subsequently underwent non-pharmacological weight reduction. In vitro experiments were performed on adipocytes...

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