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Diabetes Complications
Glycoxidation of LDL promotes apoptotic pathways and NFkappaB activation in coronary cells
April 10th, 2006
Glycoxidation of low-density lipoprotein promotes multiple apoptotic pathways and NFkappaB activation in human coronary cells According to a study from Italy, "Apoptosis of arterial cells induced by oxidized low-density lipoprotein (oxLDL) is thought to contribute to the progression of vascular dysfunction and atherogenesis. It is well established that diabetes mellitus is accompanied by both glycosylation and oxidation LDL, but the biological effects of these modified lipoproteins are poorly understood." "We demonstrate here," proposed F. de Nigris and colleagues, University Naples 2, "that glycosylated oxLDL (glc-oxLDL) promotes apoptotic signaling...
Source: Diabetes Week (2006-04-10)
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