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Diabetes Complications

Na_i ⁺ increase influences ischemia susceptibility in hearts from diabetic mice

"An important determinant of sensitivity to ischaemia is altered ion homeostasis, especially disturbances in intracellular Na⁺ (Na_i ⁺) handling. As no study has so far investigated this in type 2 diabetes, we examined susceptibility to ischemia-reperfusion in isolated hearts from diabetic db/db and control db/+ mice and determined whether and to what extent the amount of Na_i ⁺ increase during a transient period of ischaemia could contribute to functional alterations upon reperfusion," investigators in...

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