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Diabetes Control
Glucose homeostasis regulation involves estrogen receptor-alpha
April 10th, 2006
According to a study from Sweden, glucose homeostasis regulation involves estrogen receptor-alpha. "We used oestrogen receptor-alpha (ER alpha) knockout (ERKO) and receptor-beta (ER beta) knockout (BERKO) mice to investigate the mechanism(s) behind the effects of oestrogens on glucose homeostasis," wrote G. Bryzgalova and colleagues, Karolinska Institute. They continued, "Endogenous glucose production (EGP) was measured in ERKO mice using a euglycaemic-hyperinsulinaemic clamp. Insulin secretion was determined from isolated islets. In isolated muscles, glucose uptake was assayed by using radiolabelled isotopes. Genome-wide expression profiles were...
Source: Diabetes Week (2006-04-10)
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