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Diabetes Epidemiology
Interleukin-12p40 gene polymorphism did not seem to play role in type 1 diabetes mellitus
April 10th, 2006
Interleukin-12p40 gene polymorphism did not seem to play a role in type 1 diabetes mellitus in Japanese. According to a study from Japan, "The present study was undertaken to clarify a role of interleukin-12p40 gene (IL-12B) polymorphism, located on chromosome 5q33-34 (IDDM 18), in Japanese subjects with type 1 diabetes mellitus (T1DM) and autoimmune thyroid diseases (AITD). In 179 subjects with TIDM, 166 with AITD (128 with Graves' disease and 38 with Hashimoto's thyroiditis) and 115 healthy control subjects, the IL-12B 3'UTR A-C polymorphism was determined by PCR-RFLP method. In T1DM subjects, the genotype was also analyzed in relation to human leukocyte antigen...
Source: Diabetes Week (2006-04-10)
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