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Diabetes Epidemiology
IL-18 promoter polymorphisms are linked to type 1 diabetes predisposition
April 10th, 2006
IL-18 promoter polymorphisms are linked to a predisposition to type 1 diabetes. According to recent research from Iran, "IL-18, a potent IFN-gamma-inducing cytokine, is capable of polarizing the immune response to a Th1 phenotype. Recent studies have demonstrated an association between single-nucleotide polymorphisms located at positions -607 (A/C) and -137 (C/G) in the promoter region of IL-18 gene and Type 1 diabetes." Z. Mojtahedi and colleagues at Shiraz University of Medical Sciences proposed "to determine whether the same polymorphisms of the gene were associated with type 1 diabetes in Iranians. In 112 patients with type 1 diabetes and 194...
Source: Diabetes Week (2006-04-10)
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