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Diabetes Pathogenesis
Beta-cell GSIS dysfunction may show fetal survival adaptations that predispose to diabetes
April 10th, 2006
Beta-cell glucose-stimulated insulin secretion dysfunction may indicated adaptations for fetal survival that predispose offspring to adult-onset diabetes. "We determined in vivo and in vitro pancreatic islet insulin secretion and glucose metabolism in fetuses with intrauterine growth restriction (IUGR) caused by chronic placental insufficiency to identify functional deficits in the fetal pancreas that might be caused by nutrient restriction," scientists in the United States report. S.W. Limesand and colleagues at the University of Arizona found, "Plasma insulin concentrations in the IUGR fetuses were 69% lower at baseline and 76% lower after...
Source: Diabetes Week (2006-04-10)
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